Recombinant DENV-4 (strain YN/15DGR32) Envelope Glycoprotein E (Domain III)
Referência DRA314-50ug
Tamanho : 50ug
Marca : Novoprotein
Description Recombinant Dengue virus (type 4, strain YN/15DGR32) Envelope Glycoprotein E is produced by our E.coli expression system and the target gene encoding Lys574-Lys679 is expressed with a 6His tag at the C-terminus.
Accession KY672957.1
Known As Envelope Glycoprotein E; E protein
Mol Mass 12.7 kDa
APMol Mass 13 kDa, reducing conditions
Formulation Description Supplied as a 0.2 μm filtered solution of PBS, pH7.4.
Storage - Reconstituted protein solution should be stored at ≤ -20°C.
- Stable for at least 24 months when stored as instructed.
Shipping The product is shipped on dry ice pack.Upon receipt, store it immediately at the temperature listed below.
Background Dengue is the most common mosquito-borne viral disease caused by dengue virus, DENV. DENV belongs to Flaviviridae family and apparently exists as a complex of four serotypes (DENV-1, 2, 3 and 4). DENV is endemic in more than 120 countries of tropical and subtropical zones. The viral envelope glycoprotein (E protein) is thought to be responsible for the initial viral attachment to cells and for mediating cellular entry of the virus. The E protein is responsible for causing hemagglutination, infectivity, antibody neutralization, and enhancement of Fc receptor-bearing cells.The E glycoprotein is the principal component of the external surface of the DENV virion and is a dominant target of the response consisting of antibodies against DENV. E protein is divided into three functional domains, termed domains I, II and III. Domain III is responsible for binding to the receptor molecules present on the host cell membrane.