SELL Antibody
Referência OAEE00939
Tamanho : 100tests(T100)
Marca : Aviva Systems Biology
| Datasheets/Manuals | Printable datasheet for SELL Antibody |
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| Predicted Species Reactivity | Human |
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| Product Format | Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Clonality | Monoclonal |
| Clone | LT-TD180 |
| Isotype | IgG1 |
| Host | Mouse |
| Conjugation | R-PE |
| Application | FC |
| Reconstitution and Storage | 2°C to 8°C |
| Immunogen | Peripheral blood leukocytes |
| Purification | Purified by size-exclusion chromatography |
| Concentration | 20 ul / test |
| Specificity | The antibody LT-TD180 reacts with CD62L (L-selectin), a 74-95 kDa single chain type I glycoprotein expressed on most peripheral blood B lymphocytes, T lymphocytes, monocytes and granulocytes; it is also present on a subset of NK cells and certain hematopoietic malignant cells. |
| Formulation | PE |
| Storage Buffer | The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent. |
| Reference | Simone R, Zicca A, Saverino D: The frequency of regulatory CD3+CD8+CD28- CD25+ T lymphocytes in human peripheralblood increases with age. J Leukoc Biol. 2008 Dec;84(6):1454-61. Linnebacher M, Wienck A, Boeck I, Klar E: Identification of an MSI-H tumor-specific cytotoxic T cell epitope generated bythe (-1) frame of U79260(FTO). J Biomed Biotechnol. 2010;2010:841451. Kuttruff S, Koch S, Kelp A, Pawelec G, Rammensee HG, Steinle A: NKp80 defines and stimulates a reactive subset of CD8 T cells. Blood. 2009 Jan 8;113(2):358-69. Ramachandran V, Williams M, Yago T, Schmidtke DW, McEver RP: Dynamic alterations of membrane tethers stabilize leukocyte rolling on P-selectin. Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13519-24. Ding Z, Issekutz TB, Downey GP, Waddell TK: L-selectin stimulation enhances functional expression of surface CXCR4 in lymphocytes: implications for cellular activation during adhesion and migration. Blood. 2003 Jun 1;101(11):4245-52. Simon SI, Burns AR, Taylor AD, Gopalan PK, Lynam EB, Sklar LA, Smith CW: L-selectin (CD62L) cross-linking signals neutrophil adhesive functions via theMac-1 (CD11b/CD18) beta 2-integrin. J Immunol. 1995 Aug 1;155(3):1502-14. von Andrian UH, Chambers JD, Berg EL, Michie SA, Brown DA, Karolak D, Ramezani L, Berger EM, Arfors KE, Butcher EC. L-selectin mediates neutrophil rolling in inflamed venules through sialyl LewisX-dependent and -independent recognition pathways. Blood. 1993 Jul 1;82(1):182-91. Von Andrian UH, Hansell P, Chambers JD, Berger EM, Torres Filho I, Butcher EC, Arfors KE: L-selectin function is required for beta 2-integrin-mediated neutrophil adhesion at physiological shear rates in vivo. Am J Physiol. 1992 Oct;263(4 Pt 2):H1034-44. |
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| Gene Symbol | SELL |
| Gene Full Name | selectin L |
| Alias Symbols | CD62 antigen-like family member L, CD62L, gp90-MEL, L-selectin, LAM1, LECAM1, LEU8, Leukocyte adhesion molecule 1, leukocyte surface antigen Leu-8, leukocyte-endothelial cell adhesion molecule 1, LNHR, LSEL, LYAM1, lymph node homing receptor, lymphocyte adhesion molecule 1, pln homing receptor, PLNHR, TQ1. |
| NCBI Gene Id | 6402 |
| Protein Name | L-selectin |
| Description of Target | Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells (PubMed:12403782, PubMed:28489325, PubMed:28011641). Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (PubMed:12403782, PubMed:28011641). |
| Uniprot ID | P14151 |
| Protein Accession # | NP_000646.2 |
| Nucleotide Accession # | NM_000655.4 |
