Sitagliptin, also known as MK-0431, is a potent inhibitor of DPP4 with an IC50 of 19 nM in Caco-2 cell extracts. Sitagliptin is believed to exert its actions in patients with type 2 diabetes mellitus by slowing the inactivation of incretin hormones. By increasing and prolonging active incretin levels, sitagliptin increases insulin release and decreases glucagon levels in the circulation in a glucose-dependent manner. Sitagliptin demonstrates selectivity for DPP-4 and does not inhibit DPP-8 or DPP-9 activity in vitro at concentrations approximating those from therapeutic doses. [[654671-78-0]]
Referência orb1910069-100mg
Tamanho : 100mg
Marca : Biorbyt
Sitagliptin phosphate
Catalog Number: orb1910069
Catalog Number | orb1910069 |
---|---|
Category | Small Molecules |
Description | Sitagliptin, also known as MK-0431, is a potent inhibitor of DPP4 with an IC50 of 19 nM in Caco-2 cell extracts. Sitagliptin is believed to exert its actions in patients with type 2 diabetes mellitus by slowing the inactivation of incretin hormones. By increasing and prolonging active incretin levels, sitagliptin increases insulin release and decreases glucagon levels in the circulation in a glucose-dependent manner. Sitagliptin demonstrates selectivity for DPP-4 and does not inhibit DPP-8 or DPP-9 activity in vitro at concentrations approximating those from therapeutic doses. |
CAS Number | [654671-78-0] |
MW | 505.3088 |
SMILES | P(=O)(O23)(O23)O23.FC(C1=NN=C2C(23)(23)N(C(C(23)(23)[C@@](23)(C(23)(23)C3=C(23)C(=C(C(23)=C3F)F)F)N(23)23)=O)C(23)(23)C(23)(23)N21)(F)F |
Formula | C16H18F6N5O5P |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |