Remdesivir O-desphosphate acetonide impurity [1191237-80-5]
Référence HY-136597-1ml
Conditionnement : 10mM/1mL
Marque : MedChemExpress
Remdesivir O-desphosphate acetonide impurity is an impurity of Remdesivir. Remdesivir (GS-5734), a nucleoside analogue with effective antiviral activity and is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro.
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Remdesivir O-desphosphate acetonide impurity Chemical Structure
CAS No. : 1191237-80-5
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This product is a controlled substance and not for sale in your territory.
- •Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121. [Abstract]
- •Patent. US20220227776A1.
Activité biologique
Pureté et documentation
Références
Avis client
Remdesivir O-desphosphate acetonide impurity is an impurity of Remdesivir. Remdesivir (GS-5734), a nucleoside analogue with effective antiviral activity and is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro. | |
In Vitro | Remdesivir O-desphosphate acetonide impurity (analogue 21) is a 2′,3′-acetonide protected analogue of Remdesivir. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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[1]. Dustin Siegel, et al. Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. J Med Chem. 2017 Mar 9;60(5):1648-1661.
[2]. Manli Wang, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271.
* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 3.0181 mL | 15.0907 mL | 30.1814 mL | 75.4535 mL |
5 mM | 0.6036 mL | 3.0181 mL | 6.0363 mL | 15.0907 mL | |
10 mM | 0.3018 mL | 1.5091 mL | 3.0181 mL | 7.5453 mL | |
15 mM | 0.2012 mL | 1.0060 mL | 2.0121 mL | 5.0302 mL | |
20 mM | 0.1509 mL | 0.7545 mL | 1.5091 mL | 3.7727 mL | |
25 mM | 0.1207 mL | 0.6036 mL | 1.2073 mL | 3.0181 mL | |
30 mM | 0.1006 mL | 0.5030 mL | 1.0060 mL | 2.5151 mL | |
40 mM | 0.0755 mL | 0.3773 mL | 0.7545 mL | 1.8863 mL | |
50 mM | 0.0604 mL | 0.3018 mL | 0.6036 mL | 1.5091 mL | |
60 mM | 0.0503 mL | 0.2515 mL | 0.5030 mL | 1.2576 mL | |
80 mM | 0.0377 mL | 0.1886 mL | 0.3773 mL | 0.9432 mL | |
100 mM | 0.0302 mL | 0.1509 mL | 0.3018 mL | 0.7545 mL |
- Cell Cycle/DNA Damage Anti-infection
- DNA/RNA Synthesis SARS-CoV
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Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.
Keywords:
Remdesivir O-desphosphate acetonide impurity1191237-80-5DNA/RNA SynthesisSARS-CoVSARS coronavirusInhibitorinhibitorinhibit
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- Nom du produit:
- Remdesivir O-desphosphate acetonide impurity
- Cat. No.:
- HY-136597
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