Remdesivir O-desphosphate acetonide impurity [1191237-80-5]

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Conditionnement : 10mM/1mL

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Remdesivir O-desphosphate acetonide impurity is an impurity of Remdesivir. Remdesivir (GS-5734), a nucleoside analogue with effective antiviral activity and is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro.

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Remdesivir O-desphosphate acetonide impurity Chemical Structure

CAS No. : 1191237-80-5

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  • Nucleic Acids Res. 2021 Jan 8;49(D1):D1113-D1121.  [Abstract]
  • Patent. US20220227776A1.
  • Activité biologique

  • Pureté et documentation

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Remdesivir O-desphosphate acetonide impurity is an impurity of Remdesivir. Remdesivir (GS-5734), a nucleoside analogue with effective antiviral activity and is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro.

In Vitro

Remdesivir O-desphosphate acetonide impurity (analogue 21) is a 2′,3′-acetonide protected analogue of Remdesivir.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

  • [1]. Dustin Siegel, et al. Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. J Med Chem. 2017 Mar 9;60(5):1648-1661.  [Content Brief]

    [2]. Manli Wang, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271.  [Content Brief]

  • [1]. Dustin Siegel, et al. Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. J Med Chem. 2017 Mar 9;60(5):1648-1661.

    [2]. Manli Wang, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271.

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0181 mL 15.0907 mL 30.1814 mL 75.4535 mL
5 mM 0.6036 mL 3.0181 mL 6.0363 mL 15.0907 mL
10 mM 0.3018 mL 1.5091 mL 3.0181 mL 7.5453 mL
15 mM 0.2012 mL 1.0060 mL 2.0121 mL 5.0302 mL
20 mM 0.1509 mL 0.7545 mL 1.5091 mL 3.7727 mL
25 mM 0.1207 mL 0.6036 mL 1.2073 mL 3.0181 mL
30 mM 0.1006 mL 0.5030 mL 1.0060 mL 2.5151 mL
40 mM 0.0755 mL 0.3773 mL 0.7545 mL 1.8863 mL
50 mM 0.0604 mL 0.3018 mL 0.6036 mL 1.5091 mL
60 mM 0.0503 mL 0.2515 mL 0.5030 mL 1.2576 mL
80 mM 0.0377 mL 0.1886 mL 0.3773 mL 0.9432 mL
100 mM 0.0302 mL 0.1509 mL 0.3018 mL 0.7545 mL
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  • Cell Cycle/DNA Damage Anti-infection
  • DNA/RNA Synthesis SARS-CoV
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Remdesivir O-desphosphate acetonide impurity1191237-80-5DNA/RNA SynthesisSARS-CoVSARS coronavirusInhibitorinhibitorinhibit

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Remdesivir O-desphosphate acetonide impurity
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HY-136597
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