Digitonin

Biological Activity

Digitonin is a glycoside obtained from Digitalis purpurea, which could increase cell permeability by binding to cholesterol molecules and reduce tumor growth. Digitonin can increase cisplatin accumulation and reduce tumour growth in vitro.

Chemical Information

Molecular Weight	1229.31
Formula	C56H92O29
CAS Number	11024-24-1
Solubility (25°C)	DMSO 90 mg/mL Water 90 mg/mL
Storage	Powder          -20°C   3 years ;  4°C   2 years In solvent       -80°C   6 months ;  -20°C   1 month

Conversion of different model animals based on BSA (PMID: 27057123)

Species	Mouse	Rat	Rabbit	Guinea pig	Hamster	Dog
Weight (kg)	0.02	0.15	1.8	0.4	0.08	10
Body Surface Area (m2)	0.007	0.025	0.15	0.05	0.02	0.5
Km factor	3	6	12	8	5	20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the K_m factor for a mouse and then divide by the K_m factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Lindner PG, et al. Cancer Chemother Pharmacol. Digitonin enhances the efficacy of carboplatin in liver tumour after intra-arterial administration.