Digitonin
Cat# M5020-25mg
Size : 25mg
Brand : AbMole Bioscience
NSC-23471
Quality Control & Documentation
Biological Activity
Digitonin is a glycoside obtained from Digitalis purpurea, which could increase cell permeability by binding to cholesterol molecules and reduce tumor growth. Digitonin can increase cisplatin accumulation and reduce tumour growth in vitro.
Chemical Information
Molecular Weight | 1229.31 |
Formula | C56H92O29 |
CAS Number | 11024-24-1 |
Solubility (25°C) | DMSO 90 mg/mL Water 90 mg/mL |
Storage | Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Conversion of different model animals based on BSA (PMID: 27057123)
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
References
[1] Lindner PG, et al. Cancer Chemother Pharmacol. Digitonin enhances the efficacy of carboplatin in liver tumour after intra-arterial administration.