Ginkgolic Acid [22910-60-7]
Katalog-Nummer NB-64-38002-1mL
Size : 1mLx10mM(inDMSO)
Marke : Neo Biotech
Ginkgolic Acid (Synonyms: Romanicardic acid, Ginkgolic acid I, Ginkgolic acid C15:1, Ginkgolic acid (15:1))
Catalog No. T6S2123 Copy Product Info
Purity: 99.9%
Ginkgolic Acid (Romanicardic acid) C15:1 represses curli genes and prophage genes in EHEC.
Ginkgolic Acid
Copy Product InfoSynonyms Romanicardic acid, Ginkgolic acid I, Ginkgolic acid C15:1, Ginkgolic acid (15:1)
Ginkgolic Acid (Romanicardic acid) C15:1 represses curli genes and prophage genes in EHEC.
Cas No. 22910-60-7
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Purity:99.9%
Color:White to Yellow
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Product Introduction
Ginkgolic Acid AI Summary
Ginkgolic Acid exhibits a range of bioactivities across various biological targets. It has demonstrated antibacterial activity against Streptococcus mutans ATCC 25175 and Propionibacterium acnes ATCC 11827, with a Minimum Inhibitory Concentration (MIC) of 6.25 μg/mL and 0.78 μg/mL respectively. It inhibits soybean lipoxygenase-1 with an IC50 of 50000.0 nM and human tissue factor/human factor 7a with an IC50 of 32000.0 nM. In assays related to cancer, Ginkgolic Acid shows growth inhibition of several human cancer cell lines (MCF7, HCT15, A549, HT1197, SKOV3) with IC50 values varying from nanomolar to microgram per milliliter concentrations. The compound inhibits mushroom tyrosinase by 15.0% at 0.8 mM and has an ID50 of 7.5 mM for the same enzyme's activity. Moreover, Ginkgolic Acid inhibits several other enzymes and processes including HSD17B4 (IC50: 79432.8 nM), JMJD2E, Cruzain, Tau fibril formation, 15-hLO, Fructose-1,6-bisphosphate Aldolase, GCN5L2, 15-hLO-2, VDR, Polymerase Kappa, USP1/UAF1, and TDP1, with respective potencies ranging from 1584.9 nM to 79432.8 nM. It also inhibits recombination SAE1-mediated SUMOylation of RanGAP1-C2 with an IC50 of 3000.0 nM, and MMP2 (IC50: 6300.0 nM). In behavioral studies, it deters the feeding behavior of Cydia pomonella (codling moth) neonates when infested in apple fruit plugs. Additionally, it inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3-transfected CHO cells with 135.86% and 93.22% inhibition, respectively, at 10 μM. Furthermore, Ginkgolic Acid acts as an inhibitor of both SMS1 and SMS2 enzymes with an IC50 value of 1500.0 nM for each, and inhibits the SUMOylation of RanGAP1-C-terminal fragment by mediating Ubc9 and SUMO interaction inhibition with an IC50 of 3000.0 nM. It has a LogP value of 3.99, indicating its partition coefficient, and shows limited inhibition of pig pancreatic trypsin with an IC50 greater than 200,000.0 nM..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Ginkgolic Acid (Romanicardic acid) C15:1 represses curli genes and prophage genes in EHEC. |
| Targets&IC50 | SUMOylation:3.0 μM (IC50) |
| Synonyms | Romanicardic acid, Ginkgolic acid I, Ginkgolic acid C15:1, Ginkgolic acid (15:1) |
| Molecular Weight | 346.50 |
| Formula | C22H34O3 |
| Cas No. | 22910-60-7 |
| Smiles | CCCCCC\C=C/CCCCCCCc1cccc(O)c1C(O)=O |
| Relative Density. | 1.014 g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 34.70 mg/mL (100.14 mM), Sonication is recommended. DMSO: 245.00 mg/mL (707.07 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 5% DMSO+95% Saline: 1.50 mg/mL (4.33 mM), Solution. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||
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