Concanavalin A (Jackbean) (Con A)

Concanavalin A (Jackbean) (Con A)


Concanavalin A (Con A), a mannose/glucose-binding lectin isolated from Jack beans (Canavalia ensiformis), is a well-known T cell mitogen that can activate the immune system, recruit lymphocytes and elicit cytokine production. In addition to its mitogenic activity, ConA can induce programmed cell death via mitochondria-mediated apoptosis and autophagy. Interestingly, ConA has been reported to activate NFAT (nuclear factor of activated T cells), a family of transcription factors that are important in the development and function of the immune system, including T cell receptor (TCR) engagement. Specifically, binding of ConA triggers cross-linking of the TCR complex leading to T cell activation.
Concanavalin A (Con A) has 4 subunits and a molecular weight of 104 kDa. Con A is the most widely used lectin and has broad applicability. For example, immobilized Con A has been used in affinity chromatography purifications of a wide variety of glycoproteins and cellular structures.

Risultati della ricerca : 71 prodotto(i) trovato(i)

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  • Agarose 13
  • Beads 7
  • FITC 5
  • Unconjugated 5
  • TRITC 4
  • Biotin 3
  • Texas Red® 3
  • AP 2
  • Cy3 2
  • Cy5 2
  • DyLight 488 2
  • Ferritin 2
  • Gold 2
  • HRP 2
  • CF 350 1
  • CF 488A 1
  • CF 594 1
  • CF 633 1
  • CF 640R 1
  • CF 680 1
  • plant 64
  • Lectins X