Specifications

Product Data
Locus ID	3482
Synonyms	CD222; CI-M6PR; CIMPR; M6P-R; M6P/IGF2R; MPR1; MPR 300; MPR300; MPRI
Vector	pRS
E. coli Selection	Ampicillin
Mammalian Cell Selection	Puromycin
Format	Retroviral plasmids
Components	IGF2R - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 3482). 5µg purified plasmid DNA per construct 29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq	NM_000876, NM_000876.1, NM_000876.2, NM_000876.3, BC010121, BC172256, NM_000876.4
UniProt ID	P11717
Summary	This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). provided by RefSeq, Nov 2015
shRNA Design	These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact tech@clinisciences.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage	Store at -20°C
Shipping	Ambient

Product Manuals

HuSH-29 shRNA Plasmids HuSH pRS Cloning Vector HuSH RNAi Validation Vector HuSH pGFP-V-RS Cloning Vector

FAQs

shRNA (HuSH-29)

SDS

SDS for TR312220

RNAi Resources

Product overview Video shRNA Selection Guide FAQ: shRNA FAQ: siRNA FAQ; miRNA Product Brochure: RNAi QC Data for Lenti shRNA