ACVR2B Antibody - middle region
Referentie ARP45042_P050-25UL
Formaat : 25ul
Merk : Aviva Systems Biology
ACVR2B Antibody - middle region (ARP45042_P050)
| Datasheets/Manuals | Printable datasheet for anti-ACVR2B (ARP45042_P050) antibody |
|---|
| Tested Species Reactivity | Human, Mouse |
|---|---|
| Predicted Species Reactivity | Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish |
| Product Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Clonality | Polyclonal |
| Host | Rabbit |
| Application | WB |
| Reconstitution and Storage | For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Immunogen | The immunogen is a synthetic peptide directed towards the middle region of human ACVR2B |
| Purification | Affinity Purified |
| Predicted Homology Based on Immunogen Sequence | Cow: 100%; Dog: 100%; Goat: 85%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 77%; Rat: 100%; Sheep: 100%; Zebrafish: 100% |
| Peptide Sequence | Synthetic peptide located within the following region: KSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLEG |
| Concentration | 0.5 mg/ml |
| Blocking Peptide | For anti-ACVR2B (ARP45042_P050) antibody is Catalog # AAP45042 (Previous Catalog # AAPP12330) |
| Gene Symbol | ACVR2B |
|---|---|
| Gene Full Name | Activin A receptor, type IIB |
| Alias Symbols | HTX4, ACTRIIB, ActR-IIB |
| NCBI Gene Id | 93 |
| Protein Name | Activin receptor type-2B |
| Description of Target | Activin receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. ACVR2B is activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. |
| Uniprot ID | Q13705 |
| Protein Accession # | NP_001097 |
| Nucleotide Accession # | NM_001106 |
| Protein Size (# AA) | 512 |
| Molecular Weight | 58kDa |
| Protein Interactions | GDF2; BMP10; INHBA; PEG10; ERBB2IP; HSP90AA1; SMAD7; SMAD6; SMAD2; IGSF1; SYNJ2BP; SNX6; SNX2; TGFBRAP1; GDF11; MSTN; ACVR1B; SNX1; INHBC; GDF5; INHBB; BMP7; BMP2; ENG; BMP6; |
