Cereal grains, including wheat, barley, rye, maize, rice, and oats, are important sources of food and occupational allergens worldwide. Their allergenic proteins can trigger IgE-mediated food allergy, baker’s asthma, occupational respiratory allergy, and wheat-dependent exercise-induced anaphylaxis (WDEIA). Characterized cereal allergens and validated analytical reagents are essential tools for allergy research, component-resolved diagnostics (CRD), assay development, food allergen detection, and reference material production.

Major Cereal Allergenic Components

Wheat (Triticum aestivum)

• Tri a 19 (ω-5 gliadin): Major molecular marker of WDEIA.
• Tri a 14 (nsLTP): Associated with food allergy and baker’s asthma.
• Additional clinically relevant allergens include α-amylase/trypsin inhibitors, Tri a 20 and Tri a 21 (gliadins), Tri a 26 and Tri a 36 (glutenins), and other IgE-binding proteins implicated in food and occupational allergy.

Barley and Rye

• Hordeins and secalins are major prolamin storage proteins that exhibit significant immunological cross-reactivity with wheat allergens.

Maize (Zea mays)

• Zea m 14 (nsLTP): Major maize food allergen.
• Zea m 1 (β-expansin): Major maize pollen allergen associated with respiratory sensitization.

Rice and Oats

• Contain allergenic globulins, prolamins, α-amylase inhibitors, and lipid transfer proteins implicated in IgE sensitization and, in some individuals, cross-reactivity with other cereal allergens.

Research Reagents

• Recombinant and purified natural allergens.
• Allergen extracts and reference materials.
• Monoclonal and polyclonal antibodies.
• ELISA standards and calibration materials.
• DNA reference materials and certified PCR controls.
• CRD-compatible allergen components for IgE profiling.

Key Features

• High purity and batch-to-batch consistency.
• Suitable for ELISA, multiplex immunoassays, Western blotting, mass spectrometry, and, when provided as DNA reference materials, PCR-based allergen detection assays.
• Supports allergen characterization, biomarker discovery, food safety testing, diagnostic standardization, and regulatory research applications.