Glimepiride [93479-97-1]
Katalog-Nummer T0127-200mg
Size : 200mg
Marke : TargetMol
Glimepiride
(Synonyms: HOE-490, Glimperide) Copy Product Info
Glimepiride (HOE-490) is a long-acting, third-generation sulfonylurea with hypoglycemic activity.
Cas No. 93479-97-1
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:98.87%
Color:White
COA LCMS HNMR
Product Information
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Glimepiride (HOE-490) is a long-acting, third-generation sulfonylurea with hypoglycemic activity. |
| Targets & IC50 | SUR1:3 nM, SUR2B:7.3 nM, SUR2A:5.4 nM |
| In vitro | In both normal and insulin-resistant adipocytes, as well as in myocytes, Glimepiride effectively stimulates glucose transport, and the synthesis of lipids and glycogen. In cardiomyocytes, Glimepiride (IC50=6.8 nM) inhibits the pinacidil-activated whole-cell K(ATP) current. Additionally, in HEK 293 cells, Glimepiride (IC50=6.2 nM) blocks the K(ATP) channels formed by the co-expression of Kir6.2/SUR2A subunits. |
| In vivo | Within diabetic rats, Glimepiride has been shown to decrease the incidence of sperm abnormalities, enhance sperm count, and bolster antioxidant capacity. |
| Synonyms | HOE-490, Glimperide |
| Molecular Weight | 490.62 |
| Formula | C24H34N4O5S |
| Cas No. | 93479-97-1 |
| Smiles | C(NCCC1=CC=C(S(NC(N[C@H]2CC[C@H](C)CC2)=O)(=O)=O)C=C1)(=O)N3C(=O)C(CC)=C(C)C3 |
| Relative Density. | 1.29 g/cm3 |
| Storage | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 30 mg/mL (61.15 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+90% Corn Oil: 1.5 mg/mL (3.06 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||||||||||||