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> Activin A Protein, Human, Mouse, Rat, Cynomolgus, Rhesus, Recombinant

Activin A Protein, Human, Mouse, Rat, Cynomolgus, Rhesus, Recombinant

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Cat# NB-64-53763-10ug

Size : 10ug

Brand : Neo Biotech


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Activin A Protein, Human, Mouse, Rat, Cynomolgus, Rhesus, Recombinant

(Synonyms: Inhibin β A chain, Inhibin beta A chain, INHBA, Activin A) Copy Product Info

Synonyms: Inhibin β A chain, Inhibin beta A chain, INHBA, Activin A

Catalog No. TMPJ-01471 Copy Product Info
Purity: > 99.9%
Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activins, members of the TGF-beta superfamily, are disulfide-linked dimeric proteins originally purified from gonadal fluids as proteins that stimulated pituitary follicle stimulating hormone (FSH) release. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Activins are homodimers or heterodimers of the various beta subunit isoforms, while inhibins are heterodimers of a unique alpha subunit and one of the various beta subunits.
Other Forms of Activin A Protein, Human, Mouse, Rat, Cynomolgus, Rhesus, Recombinant:
Activin A Protein, Mouse, Recombinant (His)TMPY-01846
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:Greater than 95% as determined by reducing SDS-PAGE.
Appearance:Lyophilized powder
Color:White
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Product Information

Bioactivity
Bioactivity
1. Measured by its ability to induce SMAD signaling in 293-Activin A Res cells. The ED50 for this effect is 1.3 ng/mL.
2. Human intestinal organoids (ipsc source) were cultured with Activin A , BMP-4, EGF, Wnt3a, Noggin, R-spondin 1 and FGF-4 .
Description
Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activins, members of the TGF-beta superfamily, are disulfide-linked dimeric proteins originally purified from gonadal fluids as proteins that stimulated pituitary follicle stimulating hormone (FSH) release. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Activins are homodimers or heterodimers of the various beta subunit isoforms, while inhibins are heterodimers of a unique alpha subunit and one of the various beta subunits.
Species
Human/Mouse/Rat
Expression System
HEK293 Cells
TagTag Free
Accession NumberP08476
Amino AcidGly311-Ser426
ConstructionGly311-Ser426
Protein Purity
Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Activin A Protein, Human, Mouse, Rat, Cynomolgus, Rhesus, Recombinant
Endotoxin< 0.001 ng/µg (0.01 EU/µg) as determined by LAL test.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing 4 mM HCl.
ReconstitutionReconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
SynonymsInhibin β A chain, Inhibin beta A chain, INHBA, Activin A
Research Background
Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activins, members of the TGF-beta superfamily, are disulfide-linked dimeric proteins originally purified from gonadal fluids as proteins that stimulated pituitary follicle stimulating hormone (FSH) release. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Activins are homodimers or heterodimers of the various beta subunit isoforms, while inhibins are heterodimers of a unique alpha subunit and one of the various beta subunits.
Storage & Solubility Information
ShippingIn general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
StorageIt is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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Keywords

Inhibin b A chain
Related Tags: Activin A Protein, Human, Mouse, Rat, Cynomolgus, Rhesus, Recombinant chemical structure