Reagents and instruments for immunology, cell biology and molecular biology.

AMG-193 [2790567-82-5]

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Cat# NB-64-44892-5mg

Size : 5mg

Brand : Neo Biotech

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AMG-193

(Synonyms: AMG193) Copy Product Info

Synonyms: AMG193

Catalog No. T85645 Copy Product Info

Purity: 99.92%

AMG-193 is an inhibitor of the MTA-PRMT5 complex and is used in the study of cancer, respiratory diseases and digestive disorders.

Cas No. 2790567-82-5

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.92%

Appearance:Solid

Color:White

Product Information

Bioactivity

Description	AMG-193 is an inhibitor of the MTA-PRMT5 complex and is used in the study of cancer, respiratory diseases and digestive disorders.
Targets & IC50	HCT116 cells:0.13 μM
In vitro	AMG-193 is a PRMT5 inhibitor. AMG-193 significantly inhibited the proliferation of HCT116 cells with an IC50 value of 0.13 μM. [1]
Synonyms	AMG193

Chemical Properties

Molecular Weight	444.41
Formula	C₂₂H₁₉F₃N₄O₃
Cas No.	2790567-82-5
Smiles	C(=O)(C=1C=C2C3=C(C(N)=NC2=CN1)COC3)N4[C@H](COCC4)C5=CC=C(C(F)(F)F)C=C5

Storage & Solubility Information

Storage

Store at low temperature,Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (225.02 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: < 10 mg/mL (22.5 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL (11.25 mM), Sonication is recommended.

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 10 mg/mL (22.5 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2502 mL	11.2509 mL	22.5017 mL	112.5087 mL
5 mM	0.4500 mL	2.2502 mL	4.5003 mL	22.5017 mL
10 mM	0.2250 mL	1.1251 mL	2.2502 mL	11.2509 mL
20 mM	0.1125 mL	0.5625 mL	1.1251 mL	5.6254 mL
50 mM	0.0450 mL	0.2250 mL	0.4500 mL	2.2502 mL
100 mM	0.0225 mL	0.1125 mL	0.2250 mL	1.1251 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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