Amyloid-Forming peptide GNNQQNY [339091-39-3]

Amyloid-Forming peptide GNNQQNY is a biological active peptide. (This is a heptapeptide from the N-terminal prion-determining domain of the yeast protein Sup35 that forms amyloid fibrils. The availability of its detailed atomic oligomeric structure makes it a good model for studying the early stage of aggregation. The GNNQQNY dimer forms three stable sheet structures. in-register parallel, off-register parallel, and anti-parallel. The in-register parallel dimer, which is close to the amyloid beta-sheet structure, has few interpeptide hydrogen bonds, making hydrophobic interactions more important and increasing the conformational entropy compared to the anti-parallel sheet.)

836.81

C₃₃H₄₈N₁₂O₁₄

339091-39-3

Gly-Asn-Asn-Gln-Gln-Asn-Tyr

GNNQQNY

Room temperature in continental US; may vary elsewhere.

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