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> Anti-E cadherin Antibody (5W843)

Anti-E cadherin Antibody (5W843)

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Cat# NB-64-155331-25uL

Size : 25uL

Brand : Neo Biotech


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Anti-E cadherin Monoclonal Antibody (5W843)

(Synonyms: Uvomorulin, UVO, Epithelial cadherin, E-cadherin, CDHE, CDH1, CD antigen CD324, CAM 120/80, Cadherin-1) Copy Product Info

Synonyms: Uvomorulin, UVO, Epithelial cadherin, E-cadherin, CDHE, CDH1, CD antigen CD324, CAM 120/80, Cadherin-1

Catalog No. TMAB-05379 Copy Product Info
Anti-E cadherin Monoclonal Antibody (5W843) is a Rabbit antibody targeting E cadherin. Anti-E cadherin Monoclonal Antibody (5W843) can be used in WB,IHC-P,ICC/IF,FCM.
For research use only—not for human use. No sales to individuals. Use as intended only.

Product Information

Bioactivity
Description
Anti-E cadherin Monoclonal Antibody (5W843) is a Rabbit antibody targeting E cadherin. Anti-E cadherin Monoclonal Antibody (5W843) can be used in WB,IHC-P,ICC/IF,FCM.
SynonymsUvomorulin, UVO, Epithelial cadherin, E-cadherin, CDHE, CDH1, CD antigen CD324, CAM 120/80, Cadherin-1
Ig Type
IgG
Clone
5W843
Reactivity
Human
Application
WB
IHC-P
ICC/IF
FCM
Recommended Dose
WB: 1:1000-1:4000; IHC:1:200-1:1000; IF: 1:50; FCM: 1:20
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionRecombinant Monoclonal Antibody
PurificationAffinity Purified
AppearanceLiquid
Formulation1 x PBS (pH 7.4), 150 mM NaCl, 50% Glycerol, 0.02% Sodium azide and 0.05% BSA
Research BackgroundE-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Synthetic peptide of human E Cadherin
Antigen Species
Human
Gene Name
CDH1
Gene ID
999
Protein Name
Cadherin-1
Uniprot ID
P12830
Biology Area
Signal Transduction
Chemical Properties
Molecular WeightCalculated MW: 97 kDa; Observed MW: 80-120,135 kDa
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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