General Info
Host: | Rabbit |
Applications: | WB/ELISA |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-Potassium voltage-gated channel subfamily E member 3 (30-110 aa) is suitable for use in Western Blot and ELISA research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:500-2000ELISA 1:5000-20000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
Gene Symbol: | KCNE3 |
Gene ID: | 10008 |
Uniprot ID: | KCNE3_HUMAN |
Immunogen Region: | 30-110 aa |
Specificity: | KCNE3 Polyclonal Antibody detects endogenous levels of protein. |
Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 30-110 |
Description
Function | Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNC4/Kv3.4 is proposed to form the subthreshold voltage-gated potassium channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells. Associated with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion that produces a current with nearly instantaneous activation with a linear current-voltage relationship. |
Protein Name | Potassium Voltage-Gated Channel Subfamily E Member 3Mink-Related Peptide 2Minimum Potassium Ion Channel-Related Peptide 2Potassium Channel Subunit Beta Mirp2 |
Database Links | Reactome: R-HSA-5576890Reactome: R-HSA-5576893 |
Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCytoplasmPerikaryonCell ProjectionDendriteMembrane RaftColocalizes With Kcnb1 At High-Density Somatodendritic Clusters On The Surface Of Hippocampal Neurons |
Alternative Antibody Names | Anti-Potassium Voltage-Gated Channel Subfamily E Member 3 antibodyAnti-Mink-Related Peptide 2 antibodyAnti-Minimum Potassium Ion Channel-Related Peptide 2 antibodyAnti-Potassium Channel Subunit Beta Mirp2 antibodyAnti-KCNE3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance