Anti-Mouse CD32/CD16 Antibody (2.4G2)

Anti-Mouse CD32/CD16 Antibody (2.4G2) is a monoclonal inhibitory antibody against mouse CD16/CD32. Its core function is to block Fcγ receptor-mediated immune responses. By inhibiting the binding of CD16 to FcγRs, it effectively reduces foam cell formation and is widely used in research on atherosclerosis and autoimmune hematological diseases.

Anti-Mouse CD32/CD16 Antibody (2.4G2) can significantly inhibit the binding of MDALDL to J774 cells; after 24 hours of treatment, this antibody can also significantly reduce foam cell production by blocking FcγRs in RAW264.7 cells [1].
When the concentration of Anti-Mouse CD32/CD16 Antibody (2.4G2) is 0.01 mg/mL, treatment for 6 days can inhibit the formation of antibody-secreting cells (ASCs) and downregulate the levels of T cell cytokines such as IFN-γ, IL-10 and TNF-α in splenic T cells of F8-/- mice, while treatment for 4 days can interfere with the uptake and presentation of FVIII immune complexes by splenic B cells of F8-/- mice [2].

Anti-Mouse CD32/CD16 Antibody (2.4G2), administered as a single intravenous injection at a dose of 8 μg/g and given 1 hour before MAb 6A6 injection, can effectively inhibit the platelet clearance rate in γ-/- mice [3].
Anti-Mouse CD32/CD16 Antibody (2.4G2), administered as a single intraperitoneal injection at a dose of 100 μg and given 24 hours before MWReg30 injection, can reverse the pathological effects induced by the rat Anti-Mouse platelet MWReg30 in NMRI mice [4].

2.4G2

Mouse

Monoclonal

Unconjugated