General Info
Host: | Rabbit |
Applications: | IF/WB/IHC/ELISA |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-Nitric oxide synthase, inducible (117-166) is suitable for use in Immunofluorescence, Western Blot, Immunohistochemistry and ELISA research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | IF 1:50-200WB 1:500-2000 ELISA 1:10000-20000IHC 1:50-300 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
Gene Symbol: | NOS2 |
Gene ID: | 4843 |
Uniprot ID: | NOS2_HUMAN |
Immunogen Region: | 117-166 |
Specificity: | NOS2 Polyclonal Antibody detects endogenous levels of NOS2 protein. |
Immunogen: | The antiserum was produced against synthesized peptide derived from human iNOS. AA range:117-166 |
Description
Tissue Specificity | Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets. Expressed in chondrocytes. |
Post Translational Modifications | Polyubiquitinated.mediated by SPSB1, SPSB2 and SPSB4, leading to proteasomal degradation. |
Function | Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in inflammation, enhances the synthesis of pro-inflammatory mediators such as IL6 and IL8. |
Protein Name | Nitric Oxide Synthase - InducibleHepatocyte NosHep-NosInducible No SynthaseInducible NosInosNos Type IiPeptidyl-Cysteine S-Nitrosylase Nos2 |
Database Links | Reactome: R-HSA-1222556Reactome: R-HSA-392154Reactome: R-HSA-6785807Reactome: R-HSA-9033241Reactome: R-HSA-9636249 |
Cellular Localisation | CytoplasmCytosolLocalizes As Discrete Foci Scattered Throughout The Cytosol And In The Presence Of Spsb1 And Spsb4Exhibits A More Diffuse Cytosolic Localization |
Alternative Antibody Names | Anti-Nitric Oxide Synthase - Inducible antibodyAnti-Hepatocyte Nos antibodyAnti-Hep-Nos antibodyAnti-Inducible No Synthase antibodyAnti-Inducible Nos antibodyAnti-Inos antibodyAnti-Nos Type Ii antibodyAnti-Peptidyl-Cysteine S-Nitrosylase Nos2 antibodyAnti-NOS2 antibodyAnti-NOS2A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance