General Info
Host: | Rabbit |
Applications: | WB/IHC/IF/ELISA |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-Tumor necrosis factor ligand superfamily member 13B (151-200 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:500-1:2000IHC-P 1:100-300ELISA 1:20000IF 1:50-200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
Gene Symbol: | TNFSF13B |
Gene ID: | 10673 |
Uniprot ID: | TN13B_HUMAN |
Immunogen Region: | 151-200 aa |
Specificity: | TALL-1 Polyclonal Antibody detects endogenous levels of TALL-1 protein. |
Immunogen: | The antiserum was produced against synthesized peptide derived from the Internal region of human TNFSF13B at the amino acid range 151-200 |
Description
Post Translational Modifications | The soluble form derives from the membrane form by proteolytic processing. Isoform 2 is not efficiently shed from the membrane unlike isoform 1. N-glycosylated. |
Function | Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis. |
Protein Name | Tumor Necrosis Factor Ligand Superfamily Member 13bB Lymphocyte StimulatorBlysB-Cell-Activating FactorBaffDendritic Cell-Derived Tnf-Like MoleculeTnf- And Apol-Related Leukocyte Expressed Ligand 1Tall-1Cd Antigen Cd257 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 13b - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 13b - Soluble Form |
Database Links | Reactome: R-HSA-5668541Reactome: R-HSA-5669034Reactome: R-HSA-5676594 |
Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinTumor Necrosis Factor Ligand Superfamily Member 13bSoluble Form: Secreted |
Alternative Antibody Names | Anti-Tumor Necrosis Factor Ligand Superfamily Member 13b antibodyAnti-B Lymphocyte Stimulator antibodyAnti-Blys antibodyAnti-B-Cell-Activating Factor antibodyAnti-Baff antibodyAnti-Dendritic Cell-Derived Tnf-Like Molecule antibodyAnti-Tnf- And Apol-Related Leukocyte Expressed Ligand 1 antibodyAnti-Tall-1 antibodyAnti-Cd Antigen Cd257 Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 13b - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 13b - Soluble Form antibodyAnti-TNFSF13B antibodyAnti-BAFF antibodyAnti-BLYS antibodyAnti-TALL1 antibodyAnti-TNFSF20 antibodyAnti-ZTNF4 antibodyAnti-UNQ401 antibodyAnti-PRO738 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance