Size : 100mg
Synonyms: Collagenase Type I (From microorganisms), Collagenase I, 9001-12-1
| Description | Collagenase Type I is a proteolytic enzyme that primarily targets collagen and is able to break down peptide bonds in collagen. Collagenase is used as a potential therapeutic option to break up the herniated disc material, thereby reducing compression of nearby nerves. Collagenase may aid in the breakdown and reorganization of excessive scar tissue, potentially improving tissue function and appearance. Collagenase has the potential to treat intervertebral disc herniation, keloid, fat mass, lipoma, as well as Peyronie's disease and palmar fibromatosis. |
| In vivo | METHODS: To investigate the effect of Collagenase Type II (similar to Collagenase Type I) on the cornea, the corneas of New Zealand white rabbits were treated with Collagenase Type II (200 μL at 5 mg/mL) for 30 minutes. RESULTS: Collagenase Type I increases the curvature and thinning of the cornea and reduces the elastic modulus, thereby simulating the pathological characteristics of Keratoconus (KC). [1] |
| Synonyms | Collagenase Type I (From microorganisms), Collagenase I, 9001-12-1 |
| Storage | Keep away from moisture,Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O: 50 mg/mL, Sonication is recommended.  |
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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