D-Allose-13C [70849-28-4]

D-Allose-¹³C is the ¹³C labeled D-Allose (HY-128741). D-Allose exhibits antitumor activity against various cancer cells. D-Allose scavenges reactive oxygen species (ROS) and reduces oxidative stress damage. D-Allose exhibits anti-inflammatory and neuroprotective through inhibition of TLR4/PI3K/AKT signaling pathway. D-Allose exhibits antihypertensive, cryoprotective, and anti-osteoporotic activities^[1][2][5].

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

• [1]. Chen Z, et al., Recent research on the physiological functions, applications, and biotechnological production of D-allose. Appl Microbiol Biotechnol. 2018 May;102(10):4269-4278.  [Content Brief]

  [2]. Sui L, et al., Growth inhibitory effect of D-allose on human ovarian carcinoma cells in vitro. Anticancer Res. 2005 Jul-Aug;25(4):2639-44.  [Content Brief]

  [3]. Gao D, et al., Anti-inflammatory effect of D-allose in cerebral ischemia/reperfusion injury in rats. Neurol Med Chir (Tokyo). 2013;53(6):365-74.  [Content Brief]

  [4]. Akumwami S, et al., Effects of D-Allose on experimental cardiac hypertrophy. J Pharmacol Sci. 2024 Oct;156(2):142-148.  [Content Brief]

  [5]. Luo Y, et al., D-allose Inhibits TLR4/PI3K/AKT Signaling to Attenuate Neuroinflammation and Neuronal Apoptosis by Inhibiting Gal-3 Following Ischemic Stroke. Biol Proced Online. 2023 Nov 28;25(1):30.  [Content Brief]