Size : 50mg
Synonyms:
| Description | DC-BPi-11 hydrochloride is a BPTF (bromodomain PHD finger transcription factor) inhibitor with an IC50 value of 698 nM, demonstrating significant anti-proliferative effects on leukemia cells [1]. |
| In vitro | DC-BPi-11 hydrochloride at concentrations ranging from 0.1 nM to 1 μM over 24 hours inhibits BPTF in human leukemia MV-4-11 cells with an EC50 of 120 nM [1]. The same compound significantly suppresses the proliferation of these leukemia cells at 0.01 μM to 100 μM (IC50 = 0.89 μM) and reduces the expression of downstream oncogenes at concentrations between 2.5 and 20 μM over a 24-hour period [1]. Additionally, DC-BPi-11 hydrochloride dose-dependently decreases c-Myc protein levels at 0.6 to 50 μM after 24 hours [1]. This compound is deemed safe with minimal effects on normal cells [1]. |
| Molecular Weight | 433.95 |
| Formula | C20H24ClN5O2S |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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