Reagents and instruments for immunology, cell biology and molecular biology.

Epothilone B (synthetic) (EpoB) [52044-54-7]

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Cat# E3428-75-5mg

Size : 5mg

Brand : US Biological

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E3428-75 Epothilone B (synthetic) (EpoB)

Grade

Highly Purified

Shipping Temp

Storage Temp

-20°C

Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumors. Epothilone B is what is known as a microtubule stabilizer. When a cell divides, the chromosomes that will end up in each cell are separated by thin filaments called microtubules. Normally these microtubules then break down as the cell division progresses. This class of cytotoxic chemo drugs prevents that break down and thus prevents cells from completing division.

Melting Point:
95-97°C

Solubility:
Chloroform, Dichloromethane, DMSO, Ethanol, Methanol

Method for
Determining Identity:
Proton (CDCl3) NMR Spectroscopic and Mass Spectrometric Analysis

Atmosphere:
Inert gas

Storage and Stability:
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Hygroscopic. Store under inert atmosphere.

Applications

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.

Form

White Solid

Purity

~90%

References

Bollag, D.M., et al.: Cancer. Res., 55, 2325 (1995), Hardt, I.H., et al.: J. Nat. Prod., 64, 847 (2001), Gerth, K., et al.: J. Antibiot., 55, 41, 45 (2002)