Human TNF-related apoptosis-inducing ligand (TRAIL)
Catalog Number: B2018498 (1 µg)
TNF-related apoptosis-inducing ligand (TRAIL), Human, also known as Apo2 ligand, is a protein in the TNF cytokine family. It regulates cell death and aids the immune response against cancer. TRAIL selectively induces apoptosis in cancer cells, sparing normal cells. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.
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Product Description
Human TNF-related apoptosis-inducing ligand (TRAIL)
Catalog number: B2018498
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 µg
Molecular Weight or Concentration: ~18 kDa
Supplied as: Powder
Applications: a molecular tool for various biochemical applications
Storage: −20°C
Keywords: TRAIL
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.
References:
1: Guerrache A, Micheau O. TNF-Related Apoptosis-Inducing Ligand: Non-Apoptotic Signalling Cells. 2024 Mar 16;13(6):521.
2: Neve A, Corrado A, Cantatore FP. TNF-related apoptosis-inducing ligand (TRAIL) in rheumatoid arthritis: what’s new? Clin Exp Med. 2014 May;14(2):115-20.
3: von Karstedt S, Montinaro A, Walczak H. Exploring the TRAILs less travelled: TRAIL in cancer biology and therapy Nat Rev Cancer. 2017 May 24;17(6):352-366.
4: Micheau O. Regulation of TNF-Related Apoptosis-Inducing Ligand Signaling by Glycosylation Int J Mol Sci. 2018 Mar 2;19(3):715.
5: Fulda S. Tumor-necrosis-factor-related apoptosis-inducing ligand (TRAIL) Adv Exp Med Biol. 2014;818:167-80.
6: Saraei R, Soleimani M, Movassaghpour Akbari AA, Farshdousti Hagh M, Hassanzadeh A, Solali S. The role of XIAP in resistance to TNF-related apoptosis-inducing ligand (TRAIL) in Leukemia Biomed Pharmacother. 2018 Nov;107:1010-1019.
7: Gyurkovska V, Ivanovska N. Distinct roles of TNF-related apoptosis-inducing ligand (TRAIL) in viral and bacterial infections: from pathogenesis to pathogen clearance Inflamm Res. 2016 Jun;65(6):427-37.
8: Holoch PA, Griffith TS. TNF-related apoptosis-inducing ligand (TRAIL): a new path to anti-cancer therapies Eur J Pharmacol. 2009 Dec 25;625(1-3):63-72.
9: Keuper M, Wernstedt Asterholm I, Scherer PE, Westhoff MA, Möller P, Debatin KM, Strauss G, Wabitsch M, Fischer-Posovszky P. TRAIL (TNF-related apoptosis-inducing ligand) regulates adipocyte metabolism by caspase-mediated cleavage of PPARgamma Cell Death Dis. 2013 Jan 24;4(1):e474.
10: Jiang HH, Kim TH, Lee S, Chen X, Youn YS, Lee KC. PEGylated TNF-related apoptosis-inducing ligand (TRAIL) for effective tumor combination therapy Biomaterials. 2011 Nov;32(33):8529-37.
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Additional Information
| Weight | 0.15 oz |
|---|---|
| Dimensions | 2 × 0.5 × 0.5 in |