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L-Tryptophan [73-22-3]

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Cat# NB-64-00610-1g

Size : 1g

Brand : Neo Biotech

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L-Tryptophan

(Synonyms: Tryptophane, Tryptophan, L-Tryptophane, (S)-Tryptophan) Copy Product Info

Synonyms: Tryptophane, Tryptophan, L-Tryptophane, (S)-Tryptophan

Catalog No. T0439 Copy Product Info

Purity: 99.91%

L-Tryptophan (Tryptophane), an essential amino acid, is necessary for normal growth in infants and for nitrogen balance in adults. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid) and of INDOLE ALKALOIDS in plants. It can be a precursor to NIACIN, although inefficiently in mammals.

Cas No. 73-22-3

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.91%

Appearance:Solid

Color:White

Product Introduction

L-Tryptophan AI Summary

L-Tryptophan is an organic molecule characterized by its diverse bioactivities across various biological assays and enzyme systems. It demonstrates the ability to activate multiple carbonic anhydrase (CA) isoforms in species ranging from humans to microorganisms, with particular effectiveness shown in human CA2 (KA value of 27.0 µM) and other isoenzymes like CA1, CA6, and CA14. Additionally, the compound exhibits substantial lipophilicity with a logP value of 1.06 and shows a preference for binding and interacting with aqueous environments over organic phases (LogD7.4 value of -1.08). L-Tryptophan inhibits several enzymatic activities, including significant inhibitory effects on human Indoleamine 2,3-dioxygenase (IDO) and Tryptophan 2,3-dioxygenase (TDO), along with weak inhibition of the CYP3A4 enzyme. Antioxidant properties are evident, with the compound showing a range of IC50 values from 3,500 nM to over 1,000,000 nM in various oxidative assays. The compound also inhibits the aggregation of deoxy-HbS (slope of 124.0 g dl-1M-1 in the CSAT assay) and shows neuroprotective effects in ACR-intoxicated rats by modulating neurotransmitter and oxidative stress markers. The molecule is an effective inhibitor of Myeloperoxidase (MPO) with an IC50 of 2250.0 nM and also demonstrates antibacterial and antifungal activities against pathogens such as Staphylococcus aureus and Candida albicans. L-Tryptophan shows bioactivity in several viral assays, including moderate inhibition of SARS-CoV-2-related cytotoxicity in VERO-6 cells. In various physiological assays, L-Tryptophan exhibits antihypertensive activities leading to significant reductions in blood pressure in hypertensive rats and normotensive cats. The compound shows substantial inhibition of the uptake of thyroxine and tryptophan in Xenopus laevis oocytes and human LAT1. Furthermore, it displays cytotoxic effects in human HepG2 cells and weak activity against SARS-CoV-2 3CL-Pro protease. Given its multi-faceted bioactivities, L-Tryptophan holds potential for therapeutic applications involving enzyme modulation, antibacterial, antiviral, and anti-inflammatory properties while exhibiting a specific effect on blood pressure regulation and neuroprotection..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	L-Tryptophan (Tryptophane), an essential amino acid, is necessary for normal growth in infants and for nitrogen balance in adults. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid) and of INDOLE ALKALOIDS in plants. It can be a precursor to NIACIN, although inefficiently in mammals.
Synonyms	Tryptophane, Tryptophan, L-Tryptophane, (S)-Tryptophan

Chemical Properties

Molecular Weight	204.23
Formula	C₁₁H₁₂N₂O₂
Cas No.	73-22-3
Smiles	C([C@@H](C(O)=O)N)C=1C=2C(NC1)=CC=CC2
Relative Density.	1.39. Temperature:22 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 16.7 mg/mL (81.77 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1 mg/mL (4.9 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8964 mL	24.4822 mL	48.9644 mL	244.8220 mL
5 mM	0.9793 mL	4.8964 mL	9.7929 mL	48.9644 mL
10 mM	0.4896 mL	2.4482 mL	4.8964 mL	24.4822 mL
20 mM	0.2448 mL	1.2241 mL	2.4482 mL	12.2411 mL
50 mM	0.0979 mL	0.4896 mL	0.9793 mL	4.8964 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

L-TryptophanLTryptophanL TryptophanInhibitorinhibitEndogenousMetaboliteEndogenous MetaboliteAminoAcidsandDerivativesAmino Acids and Derivatives

Related Tags: L-Tryptophan chemical structure | L-Tryptophan formula | L-Tryptophan molecular weight