LRP6 Polyclonal Antibody
Cat# bs-2905R
Size : 100uL
Brand : Bioss
Formalin-fixed and paraffin embedded rat brain tissue labeled with Anti-LRP5 + LRP6 Polyclonal Antibody, Unconjugated (bs-2905R) at 1:200 followed by conjugation to the secondary antibody and DAB staining
Applications
Predicted Reactivity
| Overview | |
| Catalog # | bs-2905R |
| Product Name | LRP6 Polyclonal Antibody |
| Applications | ELISA, IHC-P, IF(IHC-P) |
| Predicted Reactivity | Human, Mouse, Rat, Dog, Cow, Pig, Horse, Rabbit |
| Specifications | |
| Conjugation | Unconjugated |
| Host | Rabbit |
| Source | KLH conjugated synthetic peptide derived from human LRP6 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Purification | Purified by Protein A. |
| Storage Buffer | 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Shipped at 4_. Store at -20_ for one year. Avoid repeated freeze/thaw cycles. |
| Target | |
| Gene ID | 4040, 4041 |
| Subcellular location | Cytoplasm, Cell membrane |
| Synonyms | ADCAD2; C030016K15Rik; Cd; FLJ90062; FLJ90421; Low density lipoprotein receptor related protein 6; LRP6_HUMAN; Low-density lipoprotein receptor-related protein 6; low-density lipoprotein receptor-related protein 6 precursor; LRP-6; LRP-5; LR3; LRP7; Low-density lipoprotein receptor-related protein 5. |
| Background | This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009]. |
| Application Dilution | |
| ELISA | 1:500-1000 |
| IHC-P | 1:200-400 |
| IF(IHC-P) | 1:50-200 |
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