CD3 APC
Catalog #
Size
Lymphocytes gated PBMCs stained with CD3 (SK7) APC (RED); Lymphocytes gated PBMCs are used as FMO control (BLUE).
| Conjugation | APC |
|---|---|
| Antigen | CD3 |
| Clone | SK7 |
| Isotype | IgG1, k |
| Applications | FC |
| Reactivity | Chimpanzee, Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Primary/Secondary | Primary |
| Format | 0.09% NaN3, 0.2% BSA (w/v), pH 7.2 |
| Storage | 2-8°C |
| Status | RUO |
Description:
The monoclonal SK7 clone recognizes antigen CD3ε epsilon, a 20KDa transmembrane cell-surface protein that belongs to the immunoglobulin superfamily. The CD3 complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. These integral membrane protein chains assemble with additional chains of the T cell receptor (TCR), as well as CD3 zeta chain, to form the T cell receptor – CD3 complex. Together with co-receptors CD4 or CD8, the complex serves to recognize antigens bound to MHC molecules on antigen-presenting cells. CD3ε is expressed on T lymphocytes, NK-T cells, and to a varying degree in developing thymocytes. CD3 plays central roles in TCR signaling, T lymphocyte activation, and antigen recognition.
The monoclonal SK7 clone recognizes antigen CD3ε epsilon, a 20KDa transmembrane cell-surface protein that belongs to the immunoglobulin superfamily. The CD3 complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. These integral membrane protein chains assemble with additional chains of the T cell receptor (TCR), as well as CD3 zeta chain, to form the T cell receptor – CD3 complex. Together with co-receptors CD4 or CD8, the complex serves to recognize antigens bound to MHC molecules on antigen-presenting cells. CD3ε is expressed on T lymphocytes, NK-T cells, and to a varying degree in developing thymocytes. CD3 plays central roles in TCR signaling, T lymphocyte activation, and antigen recognition.