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> Stachyose (hydrate) [54261-98-2]

Stachyose (hydrate) [54261-98-2]

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Cat# HY-N0299-10mg

Size : 10mg

Brand : MedChemExpress


Description

Stachyose hydrate is an orally active prebiotic that enhances the growth and activity of beneficial bacteria. Stachyose hydrate has hypoglycemic effects and can improve inflammation by regulating gut microbiota. In addition, Stachyose hydrate can induce plant cell apoptosis (Apoptosis). Stachyose hydrate can be used in research on inflammation, gastrointestinal diseases, and agriculture [1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Stachyose hydrate (3.2 mg/mL, 36 h, 48 h) induces apoptotic-like programmed cell death in Nicotiana benthamiana leaf cells, characterized by nuclear DNA fragmentation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Stachyose hydrate Related Antibodies

Apoptosis Analysis[3]

Cell Line: Nicotiana benthamiana leaf cells (tobacco, plant)
Concentration: 3.2 mg/mL
Incubation Time: 36 h, 48 h
Result: Resulted in nuclear DNA fragmentation.
Induced apoptotic-like programmed cell death.
In Vivo

Stachyose hydrate (200, 400, 600 mg/kg, p.o., once daily for 3 weeks) alleviates colitis symptoms, restores intestinal barrier integrity, and modulates pro-inflammatory and anti-inflammatory cytokine expression in DSS (HY-116282C)-induced ulcerative colitis C57BL/6J mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: DSS (HY-116282C)-induced ulcerative colitis C57BL/6J mouse model[2]
Dosage: 200, 400, 600 mg/kg
Administration: Oral gavage (p.o.), once daily for 3 weeks
Result: Significantly alleviated colitis symptoms in DSS-induced colitis mice, including reducing weight loss, lowering disease activity index (DAI), and increasing colon length, while restoring colonic epithelial barrier integrity.
Dose-dependently upregulated mRNA expression of ZO-1, Claudin-1, and Occludin, reduced IL-17, TNF-α, IL-1β, and IL-6 expression, and increased IL-10 levels.
Clinical Trial
Formula

C24H42O21.xH2O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC[C@@](O[C@@H]1CO)([C@H]([C@@H]1O)O)O[C@H]([C@@H]([C@H]2O)O)O[C@@H]([C@H]2O)CO[C@H]([C@@H]([C@H]3O)O)O[C@@H]([C@@H]3O)CO[C@H]([C@@H]([C@H]4O)O)O[C@@H]([C@@H]4O)CO.[x H2O]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (Need ultrasonic)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
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Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References