Orb1311013-1g | Taurine [107-35-7] Clinisciences

Taurine

SKU: orb1311013

Description

Taurine

Research Area

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	107-35-7
MW	125.147
Purity	99.97% (May vary between batches)
Formula	C₂H₇NO₃S
SMILES	NCCS(O)(=O)=O
Target	Autophagy,LDL,Endogenous Metabolite
Solubility	DMSO:< 1 mg/mL (insoluble or slightly soluble);H2O:88.3 mg/mL (705.55 mM)

Bioactivity

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Target IC50	Hepatocyte cells (rat):24.23 g/L\|L6 cells:> 90 μg/mL\|HEK293 cells:10 μM (EC50)
In Vivo	METHODS: To investigate the effect on the fibrotic phase of bleomycin-induced lung injury, TD139 (10 µg) was administered as an endotracheal drip to the lungs of mice with pulmonary fibrosis four times every two days. RESULTS: In the lungs of WT mice treated with TD139, there was a significant reduction in fibrosis and β-catenin activation, as well as a decrease in galectin-3 expression.TD139 significantly reduced the total amount of pulmonary collagen. At the same time, the fibrosis score decreased from 3.8±0.4 to 2.6±0.3. In the absence of bleomycin, TD139 had no effect on fibrosis.
In Vitro	METHODS: Primary alveolar epithelial cells from mice were treated with TGF-β1 (1-3 ng/mL) and TD139 (10 µM), and the expression levels of target proteins were detected by Western Blot. RESULTS: TD139 blocked TGF-β1-induced β-catenin phosphorylation. METHODS: FTC-133 and 8505C cells were treated with TD139 (0-100 µM) for 72 h. Cell viability was determined by CCK8 assay. RESULTS: TD139 decreased cell viability in a dose-dependent manner.

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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inhibit, Inhibitor, LDL, Endogenous Metabolite, EndogenousMetabolite, antioxidant, antiatherogenic, Autophagy, cardiovascular, bile, blood, 2-Aminoethanesulfonic acid, Taurine, salts, pressure-lowering, VLDL

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Human Taurine Transporter (TAUT) ELISA Kit [orb779147]
Reactivity:
Human
Dynamic Range:
0.16-10 ng/mL
Sensitivity:
0.058 ng/mL
Sizes Available: 48 T, 96 T
General Taurine (Tau) ELISA Kit [orb782058]
Reactivity:
All
Dynamic Range:
15.63-1000 ng/mL
Sensitivity:
4.33 ng/mL
Sizes Available: 48 T, 96 T
Rat Taurine Transporter (TAUT) ELISA Kit [orb781060]
Reactivity:
Rat
Dynamic Range:
0.16-10 ng/mL
Sensitivity:
0.051 ng/mL
Sizes Available: 48 T, 96 T
SLC6A6 Antibody [orb685247]
Applications:
ELISA, IHC, WB
Reactivity:
Human, Mouse
Species/Host:
Rabbit
Clonality:
Polyclonal
Conjugation:
Unconjugated
Sizes Available: 100 μl
SLC6A6 Antibody [orb25739]
Applications:
ELISA, IF, WB
Reactivity:
Human, Mouse
Species/Host:
Rabbit
Clonality:
Polyclonal
Conjugation:
Unconjugated
Sizes Available: 100 μg, 50 μg