TWEAKR (TNFRSF12A) Mouse Monoclonal Antibody [Clone ID: ITEM-4]

Specifications

Product Data
Clone Name	ITEM-4
Applications	FC
Recommended Dilution	Flow cytometry.
Reactivities	Human, Mouse
Host	Mouse
Isotype	IgG2b
Clonality	Monoclonal
Immunogen	Human CD266-transfected P815 cells
Specificity	This antibody recognizes CD266 / TWEAK R, a TNFR superfamily receptor for CD255 / TWEAK, a TNF-like weak inducer of apoptosis.
Formulation	Phosphate buffered saline (PBS) Label: PE State: Liquid purified Ig fraction Stabilizer: 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) Preservative: 15 mM sodium azide Label: Conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Conjugation	PE
Storage	Store the antibody undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Stability	Shelf life: one year from despatch.
Gene Name	tumor necrosis factor receptor superfamily member 12A
Database Link	Entrez Gene 51330 Human UniProt ID Q9NP84
Background	CD266 / TWEAK R (TNFRSF12A), also known as FN14 (fibroblast growth factor-inducible 14) is a receptor for CD255 / TWEAK, the TNF-like weak inducer of apoptosis. CD266 is expressed on endothelial cells, as well as on some cancer tissues, and plays a role in CD255-induced endothelial cell migration, proliferation, and angiogenesis. The CD255-CD266 interaction, or antibody-mediated triggering of CD266 is also able to induce apoptosis and necrosis in CD266-positive cells (including tumor cells), which might have therapeutic potential.
Synonyms	FGF-inducible 14, FN14, TNFRSF12A, Tweak receptor
Reference Data