Reagents and instruments for immunology, cell biology and molecular biology.
 
Assay for Transposase-Accessible Chromatin using sequencing kits

Assay for Transposase-Accessible Chromatin using sequencing kits

ATAC-seq (Assay for Transposase-Accessible Chromatin using sequencing) kits enable rapid genome-wide profiling of chromatin accessibility by employing a hyperactive Tn5 transposase that simultaneously fragments DNA and inserts sequencing adapters into accessible chromatin regions. This approach generates sequencing-ready libraries from isolated nuclei or permeabilized cells, providing high-resolution maps of open chromatin, transcription start site (TSS) enrichment, and nucleosome positioning. Streamlined workflows support bulk, low-input, and single-cell applications.

Key Advantages

  • Fast and Efficient Workflow: Transposition and adapter incorporation occur in a single reaction, significantly reducing library preparation time.
  • High Sensitivity and Resolution: Enables the identification of promoters, enhancers, and regulatory elements while providing nucleosome-scale fragment-size information.
  • Low-Input and Single-Cell Compatibility: Optimized protocols support applications ranging from a few hundred cells to advanced single-cell ATAC-seq workflows using droplet-based or combinatorial indexing technologies.
  • Broad Sample Compatibility: Suitable for cultured cell lines, primary cells, sorted populations, frozen tissues, and other challenging biological specimens.
  • Multi-Omics Integration: Easily combined with RNA-seq, CUT&Tag, and other epigenomic approaches to provide comprehensive insights into gene regulation.

Applications

  • Bulk ATAC-seq: Identification of differentially accessible chromatin regions and regulatory elements across biological conditions.
  • Low-Input and Rare-Cell Analysis: Profiling chromatin accessibility from limited cell numbers and valuable clinical specimens.
  • Single-Cell ATAC-seq: Characterization of cell-type-specific chromatin landscapes, heterogeneity, and developmental trajectories.
  • Multi-Omics Studies: Integration with CUT&Tag, RNA-seq, and Hi-C datasets to obtain deeper insights into gene regulatory networks.
  • Chromatin Architecture Research: Investigation of nucleosome positioning, chromatin remodeling, and epigenetic regulation mechanisms.

Frequently Asked Questions (FAQ)

How can I quickly find a atac-seq kits product?

To find a atac-seq kits product, use the search function by name, product code, supplier, brand or sub-category. You can also browse the product families listed on the page to identify an available product code, an alternative or an equivalent product.

Does CliniSciences stock several product codes in the atac-seq kits category?

Yes, CliniSciences distributes several product references in the atac-seq kits category, sourced from specialist suppliers. Depending on the product family, references may vary in terms of format, packaging, brand, supplier, technical specifications or availability.

Can I request a quote for atac-seq kits products?

Yes, you can request a quote for atac-seq kits products from the product page or by contacting CliniSciences (info@clinisciences.com). To help us process your enquiry, please provide, where possible, the product name, catalogue reference, required quantity, the supplier or brand you are looking for, and the country of delivery.

How can I find out if a atac-seq kits product is available to order?

The availability of a atac-seq kits product depends on the product code, supplier, packaging and country of delivery. For up-to-date information, please check the product details page or contact CliniSciences with the product code or name of the product you are looking for.

What should I do if I cannot find the atac-seq kits product I am looking for?

If the atac-seq kits product you are looking for does not appear in the catalogue, please contact CliniSciences with the available information: product name, reference number, supplier, brand, format or packaging. The team will be able to search for the reference number within its network of suppliers or suggest an available alternative.

Are all atac-seq kits products available under the same terms and conditions?

No. Ordering, delivery, storage and documentation conditions may vary depending on the product type, the supplier and the applicable regulations. Certain product codes may require specific approval, specialised transport, a safety data sheet or additional information prior to ordering.

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