Size : 25mg
Synonyms: Tomoxetine, HSDB-7352, HSDB7352, HSDB 7352
| Description | Atomoxetine (HSDB 7352) is a selective norepinephrine inhibitor that may cause an increase in blood pressure by increasing norepinephrine concentrations in peripheral sympathetic neurons .Atomoxetine is a highly selective antagonist of presynaptic norepinephrine transporters with little or no affinity for other norepinephrine receptors or other neurotransmitter transporters or receptors, but has little or no affinity for 5- hydroxytryptamine transporter. Atomoxetine selectively inhibits reuptake of norepinephrine and can be used to treat adolescents with ADHD and chronic tics. |
| Targets & IC50 | Dopamine:1451 nM, 5-HT:77 nM, Norepinephrine:5 nM |
| In vitro | Atomoxetine (Tomoxetine) exhibits state- and dose-dependent interaction with the human cardiac sodium channel (hNav1.5) in tsA201 cells, with concentrations ranging from 1 to 100 µM and exposure durations of 0.5 to 20 seconds.[2] |
| In vivo | Administration of Atomoxetine (Tomoxetine) at doses of 0.3-3 mg/kg (i.p.) for a duration of 0-4 hours in male Sprague-Dawley rats results in a threefold increase in extracellular norepinephrine and dopamine levels, along with an increase in Fos expression observed in the prefrontal cortex.[1] Furthermore, Atomoxetine (Tomoxetine) at doses of 0.1-5 mg/kg (i.p. and p.o.) administered over a period of 14 days in spontaneously hypertensive rats demonstrates the potential to ameliorate ADHD-related behaviors in rats.[3] |
| Synonyms | Tomoxetine, HSDB-7352, HSDB7352, HSDB 7352 |
| Molecular Weight | 255.35 |
| Formula | C17H21NO |
| Cas No. | 83015-26-3 |
| Smiles | [C@@H](OC1=C(C)C=CC=C1)(CCNC)C2=CC=CC=C2 |
| Relative Density. | 1.023g/cm3 |
| Storage | Store at low temperature Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: Soluble |
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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