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Dexrazoxane [24584-09-6]

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Cat# NB-64-11561-100mg

Size : 100mg

Brand : Neo Biotech

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Dexrazoxane

(Synonyms: ICRF-187) Copy Product Info

Synonyms: ICRF-187

Catalog No. T22305 Copy Product Info

Purity: 99.88%

Dexrazoxane (ICRF-187) is an anticancer drug used to block mitosis and arrest dividing cells. It is an iron chelator and provides cardioprotection against anthracycline toxicity.

Cas No. 24584-09-6

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.88%

Appearance:Solid

Color:White to Yellow

Product Information

Dexrazoxane AI Summary

Dexrazoxane is a multifaceted compound studied for its pharmacokinetics, bioactivity, and potential therapeutic applications. It has a total body clearance of 3.1 mL/min/kg and a renal clearance of 1.4 mL/min/kg, indicating how it is processed and eliminated. With a volume of distribution at steady state of 0.55 L/kg and a half-life of 2.5 hours, it distributes well in the body and remains active for a moderate duration. The compound shows involvement in various liver enzyme activities but exhibits no bioactivities related to drug-induced liver injury. It demonstrates inhibitory effects in NCI human tumor cell line growth assays and has antiviral activity against SARS-CoV-2. Additionally, Dexrazoxane has moderate antimalarial activity against Plasmodium species and impacts epirubicin pharmacokinetics in dogs. In terms of toxicity, it exhibits elevated serum enzyme activities indicative of moderate liver toxicity, but no severe liver conditions were reported. The compound shows metal chelation capability and possesses cardioprotective, antiproliferative, and specific enzyme inhibitory activities, though with generally low potency. It also induces DNA damage in human HCT15 cells and demonstrates minimal activity against certain viral infections in VERO-6 cells. Despite these diverse properties, it exhibits low binding affinity and inhibitory activity in various in vitro assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Dexrazoxane (ICRF-187) is an anticancer drug used to block mitosis and arrest dividing cells. It is an iron chelator and provides cardioprotection against anthracycline toxicity.
Synonyms	ICRF-187

Chemical Properties

Molecular Weight	268.27
Formula	C₁₁H₁₆N₄O₄
Cas No.	24584-09-6
Smiles	C[C@@H](CN1CC(=O)NC(=O)C1)N1CC(=O)NC(=O)C1
Relative Density.	1.333 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 57 mg/mL (212.47 mM), Sonication is recommended.

Methanol: 1.25 mg/mL (4.66 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.46 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Methanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7276 mL	18.6379 mL	37.2759 mL	186.3794 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.7455 mL	3.7276 mL	7.4552 mL	37.2759 mL
10 mM	0.3728 mL	1.8638 mL	3.7276 mL	18.6379 mL
20 mM	0.1864 mL	0.9319 mL	1.8638 mL	9.3190 mL
50 mM	0.0746 mL	0.3728 mL	0.7455 mL	3.7276 mL
100 mM	0.0373 mL	0.1864 mL	0.3728 mL	1.8638 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

NSC-169780NSC169780NSC 169780InhibitorinhibitICRF187ICRF 187DexrazoxaneADR-529ADR529ADR 529

Related Tags: Dexrazoxane chemical structure | Dexrazoxane formula | Dexrazoxane molecular weight