Reagents and instruments for immunology, cell biology and molecular biology.

Epothilone D (KOS 862)

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Cat# E3428-75C-5mg

Size : 5mg

Brand : US Biological

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E3428-75C Epothilone D (KOS 862)

Grade

Highly Purified

Shipping Temp

Storage Temp

-20°C

Epothilones are polyketid. Potent microtubule stabilizer. Epothilone D is a more potent microtubule stabilizer in vitro than epothilone A or B. In vitro, Epothilone D showed potent cytotoxicity in a panel of human tumor cell lines, with similar potency to paclitaxel. It also showed definite advantage over paclitaxel in drug-resistant cell lines, and retained its cytotoxicity against a multidrug resistant cell line over-expressing P-glycoprotein.

Synonyms:
12,13-Deoxyepothilone B, EpoA; (4S,7R,8S,9S,13Z,16S)-4,8-Dihydroxy-5,5,7,9,13-pentamethyl-16-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]oxacyclohexadec-13-ene-2,6-dione; (-)-Desoxyepothilone B; (-)-Epothilone D; KOS 862

CAS No:
189453-10-9

Molecular Formula:
C27H41NO5S

Molecular Weight:
477.66

Appearance:
White to off-white powder

Purity:
≥99%

Melting Point:
63-66°C

Solubility:
Dichloromethane, Ether, Ethyl Acetate, Methanol

Storage and Stability:
Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Applications

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.

Form

White to off-white powder

Purity

≥99%

References

1. Brunden KR, Zhang B, Carroll J, Yao Y, Potuzak JS, Hogan AM, Iba M, James MJ, Xie SX, Ballatore C, Smith AB 3rd, Lee VM, Trojanowski JQ. Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy. J Neurosci. 2010 Oct 13;30(41):13861-6. doi:10.1523/JNEUROSCI.3059-10.2010. PubMed PMID: 20943926; PubMed Central PMCID: PMC2958430.