Reagents and instruments for immunology, cell biology and molecular biology.

INT [146-68-9]

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Cat# T19374-500mg

Size : 500mg

Brand : TargetMol

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INT

(Synonyms: p-Iodonitrotetrazolium Violet, Iodonitrotetrazolium chloride) Copy Product Info

Iodonitrotetrazolium chloride (INT), serves as the electron acceptor in a range of dehydrogenase colorimetric analyses.

Cas No. 146-68-9

For research use only—not for human use. No sales to individuals. Use as intended only.

Batch Information

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Purity:99.43%

Color:Yellow

Resource Download

COA HPLC HNMR

Product Introduction

INT AI Summary

INT exhibits antimalarial activity against Plasmodium falciparum with an IC50 value of 81000.0 nM in an LDH reporter assay. It also demonstrates toxicity in CHO cells with an IC50 value of 49000.0 nM, leading to a ratio of IC50 for CHO cells to IC50 for Plasmodium falciparum of 0.6, suggesting potential selectivity for the parasite over mammalian cells. However, it shows low binding affinity with an IC50 value greater than 2500000.0 nM in the displacement of SYBR green I from salmon testes DNA assay..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Iodonitrotetrazolium chloride (INT), serves as the electron acceptor in a range of dehydrogenase colorimetric analyses.
Synonyms	p-Iodonitrotetrazolium Violet, Iodonitrotetrazolium chloride

Chemical Properties

Molecular Weight	505.7
Formula	C₁₉H₁₃ClIN₅O₂
Cas No.	146-68-9
Smiles	[Cl-].[O-][N+](=O)c1ccc(cc1)-n1nc(n[n+]1-c1ccc(I)cc1)-c1ccccc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Store at low temperature,Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 121.25 mg/mL (239.77 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 2 mg/mL (3.95 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9775 mL	9.8873 mL	19.7746 mL	98.8728 mL
5 mM	0.3955 mL	1.9775 mL	3.9549 mL	19.7746 mL
10 mM	0.1977 mL	0.9887 mL	1.9775 mL	9.8873 mL
20 mM	0.0989 mL	0.4944 mL	0.9887 mL	4.9436 mL
50 mM	0.0395 mL	0.1977 mL	0.3955 mL	1.9775 mL
100 mM	0.0198 mL	0.0989 mL	0.1977 mL	0.9887 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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