Wortmannin [19545-26-7]
Cat# T6283-5mg
Size : 5mg
Brand : TargetMol
Wortmannin
(Synonyms: SL-2052, KY-12420) Copy Product Info
Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible. Wortmannin is also an inhibitor of PlK1 and PlK3 (IC50=5.8/48 nM) that blocks autophagy.
Cas No. 19545-26-7
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.80%
Appearance:Solid
Color:White to Yellow
COA HNMR LCMS
Product Information
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible. Wortmannin is also an inhibitor of PlK1 and PlK3 (IC50=5.8/48 nM) that blocks autophagy. |
| Targets & IC50 | PLK3:48 nM, PI3K:3 nM, ATR:1.8 μM, MLCK:200 nM, ATM:150 nM, DNA-PK:16 nM |
| In vitro | METHODS: Human breast cancer cells MCF-7 were treated with Wortmannin (50-500 nM) for 24 h. Cell death was detected by Trypan blue exclusion assay. RESULTS: Wortmannin induced cell death in MCF-7 cells in a concentration-dependent manner with an IC50 of 400 nM. [1] METHODS: Human breast cancer cells MCF-7 were treated with Wortmannin (6.25-50 nM) for 24 h. The expression levels of target proteins were detected by Western Blot. RESULTS: Concentration-dependent reduction of p-Akt and NF-κB p65 expression was induced by Wortmannin. [2] |
| In vivo | METHODS: To determine whether activation of the insulin pathway and brain enlargement were responsible for fatal seizures, Wortmannin (1.5 mg/kg) was administered orally to Pcmt1-/- mice once a day for twenty-two days. RESULTS: Wortmannin reduced the average brain size of Pcmt1-/- mice to within 6% of that of controls and nearly doubled the lifespan of Pcmt1-/- mice, with a survival rate of 60% of the original population. [3] METHODS: To investigate antitumor activity, Wortmannin (0.25-1 mg/kg) was injected intravenously three times a week for three weeks into SCID mice bearing the human breast cancer tumor MDA-MB-231. RESULTS: Wortmannin significantly inhibited tumor metastasis and angiogenesis. [4] |
| Synonyms | SL-2052, KY-12420 |
| Molecular Weight | 428.43 |
| Formula | C23H24O8 |
| Cas No. | 19545-26-7 |
| Smiles | C[C@@]12C3=C([C@]4([C@](C)(C[C@H]3OC(C)=O)C(=O)CC4)02)C(=O)C5=C1C(C(=O)O[C@@H]2COC)=CO5 |
| Relative Density. | 1.39 g/cm3 |
| Storage | Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 2.1 mg/mL (4.9 mM), Heating is recommended. DMSO: 21.4 mg/mL (49.95 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||||||||||||