As a globally leading biotechnology innovator, Creative Biogene integrates gene editing as its cornerstone and bioscience as its frontier, delivering end-to-end solutions across gene therapy, drug development, agricultural biotechnology, and industrial microbial engineering. With a commitment to accelerating scientific discovery, Creative Biogene bridges the gap between research and real-world applications through its comprehensive technology platforms and tailored services, positioning themselves as a trusted partner in both CRO and CDMO domains.
Core Competencies & Service
Creative Biogene has established a comprehensive biotechnology service framework. This cohesive architecture ensures both robust functionality and adaptability in meeting diverse client needs.
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Category
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Service
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Description
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Gene Editing
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Precision Genome Engineering
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Leveraging CRISPR-Cas9 and base editing technologies for customized services in gene knockout, knock-in, and point mutations across mammalian cells, plants, and industrial microbes. HIEF™ platform enables rapid stable cell line generation for antibody drug development, CAR-T/NK cell therapies, and recombinant protein production.
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Viral Vector Solutions
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Specializing in high-titer viral vector production (AAV, lentivirus, adenovirus) for gene therapy and vaccine development. Key offerings include tissue-specific AAV serotypes, oncolytic viruses, and GMP-grade lentiviral vectors for clinical trials.
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RNA Technology
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RNA Synthesis & Delivery
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Supports full-spectrum nucleic acid drug development, including mRNA/circRNA design, chemical modifications (e.g., GalNAc conjugation, 5’-capping), and advanced delivery systems (lipid nanoparticles, exosomes, polymer-based carriers). Includes siRNA therapeutics, self-amplifying RNA vaccines, and RNA-based gene editing tools.
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Functional & Mechanistic Studies
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RNA-seq, single-cell sequencing, and spatial transcriptomics services for deep insights into gene regulation, with shRNA/miRNA libraries to facilitate high-throughput target validation.
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Microbial Engineering
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Strain Development & Fermentation
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Engineering high-performance microbial strains (E. coli, Bacillus, Streptomyces) for enzyme production, recombinant biologics, and next-generation probiotics, with scalable fermentation from bench-scale to 1kL bioreactors.
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cGMP Compliance
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Services include 16S/ITS sequencing, MALDI-TOF MS-based identification, endotoxin testing, and stability studies, ensuring regulatory compliance for industrial and pharmaceutical applications.
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Preclinical Development
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Target-based Drug Screening
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Screening and profiling across hot drug targets including GPCRs, ion channels, kinases, phosphatases, Nuclear receptors, Proteases, E3s, DUBs, Methyltransferase, Demethylase, etc.
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In Vivo/In Vitro Models
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PDX/PDO tumor models, zebrafish toxicity platforms (cardio/hepatic/renal assessments), and metabolic disease models (NAFLD, diabetes) to accelerate efficacy and safety profiling.
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ADME-Tox & Pharmacokinetics
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Integrated services include CYP450 phenotyping, PAMPA permeability assays, plasma protein binding studies, and in vivo PK/PD modeling to support IND-enabling workflows.
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Core Product Portfolio
Creative Biogene provides a diverse range of biotechnology products, including transfected stable cell lines, premade viral particles, VLPs, cloning tools, oligonucleotides, enzymes, RNA interference reagents, adjuvants, and lab equipment. Designed for applications in gene editing, vaccine development, drug screening, and biopharmaceutical production, our products support cutting-edge research.
Global Presence & Strategic Collaboration
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