Reagents and instruments for immunology, cell biology and molecular biology.

KRAS probe for ISH CE/IVD - Gastrointestinal pathology

The KRAS (KRAS proto-oncogene, GTPase) gene located on chromosome 12p12.1 is a member of the RAS gene family comprising HRAS, KRAS, and NRAS, all of which encode a 21 kDa protein. The wildtype proteins play a pivotal role in cell proliferation, differentiation, and senescence.

Mutations of KRAS are frequently found in epithelial malignancies and lead to activation of the downstream mitogen-activated protein kinase (MAPK) resulting in unchecked cellular proliferation and tumor progression.

Amplifications of KRAS and the impli-cations in tumorigenesis are not as well characterized as KRAS mutations.

However, recent studies using different methods found amplification of KRAS or copy number gain of the 12p12.1 region including KRAS in various primary tumors, as e.g. in lung, colorectal, pancreatic, and gastric cancers.

For non-small cell lung cancer (NSCLC) patients KRAS amplification as assessed by Fluorescence in situ Hybridization (FISH) was detected in about 15% of the tumors. Amplification of KRAS was found to be correlated with poor prognosis and may act synergistically with KRAS mutations to promote tumor progression.

FISH

Frequently Asked Questions (FAQ)

Where can I find kras products on the CliniSciences website?

kras products are available in this section and can be sorted by product families or sub-categories, such as FISH. You can browse the catalogue tree or use the search bar with a product name, catalogue reference, brand or supplier.

What types of products are available in the kras category?

The kras category brings together various product references, consumables, reagents, kits, instruments or laboratory solutions, depending on the relevant product family. The FISH sub-categories allow you to find the products that meet your needs more quickly.

How can I quickly find a kras product?

To find a kras product, use the search function by name, product code, supplier, brand or sub-category. You can also browse the product families listed on the page to identify an available product code, an alternative or an equivalent product.

Does CliniSciences stock several product codes in the kras category?

Yes, CliniSciences distributes several product references in the kras category, sourced from specialist suppliers. Depending on the product family, references may vary in terms of format, packaging, brand, supplier, technical specifications or availability.

Can I request a quote for kras products?

Yes, you can request a quote for kras products from the product page or by contacting CliniSciences (info@clinisciences.com). To help us process your enquiry, please provide, where possible, the product name, catalogue reference, required quantity, the supplier or brand you are looking for, and the country of delivery.

How can I find out if a kras product is available to order?

The availability of a kras product depends on the product code, supplier, packaging and country of delivery. For up-to-date information, please check the product details page or contact CliniSciences with the product code or name of the product you are looking for.

What should I do if I cannot find the kras product I am looking for?

If the kras product you are looking for does not appear in the catalogue, please contact CliniSciences with the available information: product name, reference number, supplier, brand, format or packaging. The team will be able to search for the reference number within its network of suppliers or suggest an available alternative.

Are all kras products available under the same terms and conditions?

No. Ordering, delivery, storage and documentation conditions may vary depending on the product type, the supplier and the applicable regulations. Certain product codes may require specific approval, specialised transport, a safety data sheet or additional information prior to ordering.