Amyloid Precursor Protein (APP) (APP695) (18-38) Mouse Monoclonal Antibody [Clone ID: 3E9]
CAT#: AM26575PU-N
Amyloid Precursor Protein (APP) (APP695) (18-38) mouse monoclonal antibody, clone 3E9, Azide Free
Specifications
Product Data | |
Clone Name | 3E9 |
Applications | WB |
Recommended Dilution | Western blot: 5-10 μg/ml for chemiluminescence detection system. For details see protocol below. |
Reactivities | Human, Mouse |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Synthetic peptide corresponding to APP695 (18-38 aa) |
Specificity | This antibody reacts with Amyloid Precursor Protein. |
Formulation | PBS (pH 7.2) State: Azide Free State: Lyophilized Ig fraction Stabilizer: 1% sucrose Preservative: 0.09% NaN3 |
Reconstitution Method | Restore with 100 μL of distilled water. |
Purification | Protein A agarose |
Conjugation | Unconjugated |
Storage | Prior to reconstitution store at 2-8°C. |
Stability | Shelf life: one year from despatch. |
Gene Name | amyloid beta precursor protein |
Database Link | |
Background | Alzheimer's disease (AD) is the most common form of dementia in the elderly. The neuropathological hallmarks are neurofibrillary tangles and senile plaques. The major protein component of the plaques consists of 39-42 amino acids peptide (ß-amyloid/Aß). Aß occurs in two predominant forms with different COOH-termini, Aß 40 and Aß 42, and overproduction of Aß 42 has been suggested to be the cause of familial earlyonset AD. Aß generation depends on proteolytic cleavage of the amyloid precursor protein (APP) by two proteases: ß-secretase and ?-secretase. Recent study suggested that a transmembrane aspartic protease, termed ß-site APP-cleaving enzyme (BACE), functionally acts as the ß-secretase. |
Synonyms | Alzheimer disease amyloid protein, Amyloid Precursor Protein, ABPP, APPI, PreA4, Cerebral vascular amyloid peptide, CVAP |
Note | This product was originally produced by MBL International. Protocol: SDS-PAGE & Western Blotting |
Reference Data |
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