Activin Receptor Type IA (ACVR1) (NM_001105) Human Untagged Clone
CAT#: SC119434
ACVR1 (untagged)-Human activin A receptor, type I (ACVR1), transcript variant 1
Product Images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Symbol | Activin Receptor Type IA |
| Synonyms | ACTRI; ACVR1A; ACVRLK2; ALK2; FOP; SKR1; TSRI |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | >OriGene ORF sequence for NM_001105 edited ATGGTAGATGGAGTGATGATTCTTCCTGTGCTTATCATGATTGCTCTCCCCTCCCCTAGT ATGGAAGATGAGAAGCCCAAGGTCAACCCCAAACTCTACATGTGTGTGTGTGAAGGTCTC TCCTGCGGTAATGAGGACCACTGTGAAGGCCAGCAGTGCTTTTCCTCACTGAGCATCAAC GATGGCTTCCACGTCTACCAGAAAGGCTGCTTCCAGGTTTATGAGCAGGGAAAGATGACC TGTAAGACCCCGCCGTCCCCTGGCCAAGCTGTGGAGTGCTGCCAAGGGGACTGGTGTAAC AGGAACATCACGGCCCAGCTGCCCACTAAAGGAAAATCCTTCCCTGGAACACAGAATTTC CACTTGGAGGTTGGCCTCATTATTCTCTCTGTAGTGTTCGCAGTATGTCTTTTAGCCTGC CTGCTGGGAGTTGCTCTCCGAAAATTTAAAAGGCGCAACCAAGAACGCCTCAATCCCCGA GACGTGGAGTATGGCACTATCGAAGGGCTCATCACCACCAATGTTGGAGACAGCACTTTA GCAGATTTATTGGATCATTCGTGTACATCAGGAAGTGGCTCTGGTCTTCCTTTTCTGGTA CAAAGAACAGTGGCTCGCCAGATTACACTGTTGGAGTGTGTCGGGAAAGGCAGGTATGGT GAGGTGTGGAGGGGCAGCTGGCAAGGGGAAAATGTTGCCGTGAAGATCTTCTCCTCCCGT GATGAGAAGTCATGGTTCAGGGAAACGGAATTGTACAACACTGTGATGCTGAGGCATGAA AATATCTTAGGTTTCATTGCTTCAGACATGACATCAAGACACTCCAGTACCCAGCTGTGG TTAATTACACATTATCATGAAATGGGATCGTTGTACGACTATCTTCAGCTTACTACTCTG GATACAGTTAGCTGCCTTCGAATAGTGCTGTCCATAGCTAGTGGTCTTGCACATTTGCAC ATAGAGATATTTGGGACCCAAGGGAAACCAGCCATTGCCCATCGAGATTTAAAGAGCAAA AATATTCTGGTTAAGAAGAATGGACAGTGTTGCATAGCAGATTTGGGCCTGGCAGTCATG CATTCCCAGAGCACCAATCAGCTTGATGTGGGGAACAATCCCCGTGTGGGCACCAAGCGC TACATGGCCCCCGAAGTTCTAGATGAAACCATCCAGGTGGATTGTTTCGATTCTTATAAA AGGGTCGATATTTGGGCCTTTGGACTTGTTTTGTGGGAAGTGGCCAGGCGGATGGTGAGC AATGGTATAGTGGAGGATTACAAGCCACCGTTCTACGATGTGGTTCCCAATGACCCAAGT TTTGAAGATATGAGGAAGGTAGTCTGTGTGGATCAACAAAGGCCAAACATACCCAACAGA TGGTTCTCAGACCCGACATTAACCTCTCTGGCCAAGCTAATGAAAGAATGCTGGTATCAA AATCCATCCGCAAGACTCACAGCACTGCGTATCAAAAAGACTTTGACCAAAATTGATAAT TCCCTCGACAAATTGAAAACTGACTGTTGA >OriGene 5' read for NM_001105 unedited NGTAACGTCGAAATTTGTATACGACTCATATAGGCGGCCGCGNAATTCGCACGAGGGCGT GGAGCGGGGGTCTCAGCCTGGNACATTGGTAAGCGTCACACTGCCAAAGTGAGAGCTGCT GGAGAACTCATAATCCCAGGAACGCCTCTTCTACTCTCCGAGTACCCCAGTGACCAGAGT GAGAGAAGCTCTGAACGAGGGCACGCGGCTTGAAGGACTGTGGGCAGATGTGACCAAGAG CCTGCATTAAGTTGTACAATGGTAGATGGAGTGATGATTCTTCCTGTGCTTATCATGATT GCTCTCCCCTCCCCTAGTATGGAAGATGAGAAGCCCAAGGTCAACCCCAAACTCTACATG TGTGTGTGTGAAGGTCTCTCCTGCGGTAATGAGGACCACTGTGAAGGCCAGCAGTGCTTT TCCTCACTGAGCATCAACGATGGCTTCCACGTCTACCAGAAAGGCTGCTTCCAGGTTTAT GAGCAGGGAAAGATGACCTGTAAGACCCCGCCGTCCCCTGGCCAAGCTGTGGAGTGCTGC CAAGGGGACTGGTGTAACAGGAACATCACGGCCCAGCTGCCCACTAAAGGAAAATCCTTC CCTGGAACACAGAATTTCCACTTGGAGGTTGGCCTCATTATTCTCTCTGTAGTGTTCGCA GTATGTCTTTTAGCCTGCCTGCTGGGAGTTGCTCTCCGAAAATTTAAAAGGCGCAACCAA GAACGCCTCAATCCCCGAGACGTGGAGTATGGCACTATCGAAGGGCTCATCACCACCAAT GGTTGGAGACAGCACTTTAGCAGATTTATTGGGGATCATTCGTGTACATCAGGGAGTGGC TCTGGTCTTCCTTTTCTGGTACAAAGAACAGTGGCTCGCCAGATTACCTGTTGGGN >OriGene 3' read for NM_001105 unedited CGGCCGCAATCTANAGTCGAGTTTTTTTTTTTTTTTTTTGACTTGAAACAGTTTATTTAA TTTATACAAATAACTACTAAATACAAAAAGTAGATTAAAACAAAATAGTTATTTTTTTTC TGGCAGAGTTTAAATGCACGTAATGGATAATTCTGAAGAAAATGCATTTTCCCCGTAGCG TTCAGGACTAAAATTCTACTGAAATCTTTGCTTCTAAATCAGTAATATATTCGGTGGTGT CACGTGGGTAATGGCTAAATACGTTCTGCATATGAACTGAAAAAAAGTTACAGTCTACAC ACATACAAATGTGAAGCACTTAAAATGTGATTTTAACTGATAATAAAAGAAAATGTCCAT TTTAGAGTATAGTATTAAAAACATTTCTGTAATAAAATCATAAGACCACATAAAAATAAG CTTTAACATATGCACAAAGCAGTTTTGTAAAAACTACTAAGTGCACAAGTAATAAATAAT TTGCAAAGTTGTGTATAAACAATTCCTAATGTTCGGCATTATTGTAAACATCAGCACATG TGTAAAATGCAGCAAAGTCTGACATTACATTTTGTTTTGCCAAATTGAATTCCTATTATC CAAAGACAGACCAGTGGAGTACGCAGCCAACATTTTGGCAAGTTGGGTCTTTAAAATTAA GAGTAACAGTGCAAGTAGGAATGCAAAGAATTCCTAGTGCNATANAGAAGAGAGCACAGG CCATATTGCTGATTTAAAATCACCACCTCCTTTGAGTTNCCGTGGNGAGTGTCTAGGAGA CTTGTGAAAGCTATGCAANGCCACTGACTTAATGCCCAGATCTCTTTTAGATTTCTCTGT NGTCCTCCAGTCCCTACCCTTGCACAGTGTCTGTTCACATTATCTCTGCATGGTGACAGT TCGGAAAGGCCCANTCCAGTCATCGACGAGTTTAGGTGTTTGATGCTCCCACACATGCTG GTCNACGTTTGCTGTCAAACGCATT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_001105 |
| Insert Size | 3000 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at info@clinisciences.com The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_001105.2, NP_001096.1 |
| RefSeq Size | 2952 bp |
| RefSeq ORF | 1530 bp |
| Locus ID | 90 |
| UniProt ID | Q04771 |
| Cytogenetics | 2q24.1 |
| Domains | Activin_recp, pkinase, TyrKc, S_TKc, GS |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane |
| Protein Pathways | Cytokine-cytokine receptor interaction, TGF-beta signaling pathway |
| Gene Summary | Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008] Transcript Variant: This variant (1) is the longer transcript. Both variants 1 and 2 encode the same protein. |
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Resources
Other Versions
| SKU | Description | Size | |
|---|---|---|---|
| RC207486 | ACVR1 (Myc-DDK-tagged)-Human activin A receptor, type I (ACVR1), transcript variant 1 | 474,00 EUR | |
| RC207486L1 | Lenti ORF clone of Human activin A receptor, type I (ACVR1), transcript variant 1, Myc-DDK-tagged | 774,00 EUR | |
| RC207486L2 | Lenti ORF clone of Human activin A receptor, type I (ACVR1), transcript variant 1, mGFP tagged | 774,00 EUR | |
| RC207486L3 | Lenti ORF clone of Human activin A receptor, type I (ACVR1), transcript variant 1, Myc-DDK-tagged | 774,00 EUR | |
| RC207486L4 | Lenti ORF clone of Human activin A receptor, type I (ACVR1), transcript variant 1, mGFP tagged | 774,00 EUR | |
| RG207486 | ACVR1 (tGFP-tagged) - Human activin A receptor, type I (ACVR1), transcript variant 1 | 674,00 EUR | |
| SC323384 | ACVR1 (untagged)-Kinase deficient mutant (K235M) of Human activin A receptor, type I (ACVR1), transcript variant 1 | 712,00 EUR |