General Info
Host: | Rabbit |
Applications: | IF/ELISA |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-G-protein coupled receptor 143 (151-200 aa) is suitable for use in Immunofluorescence and ELISA research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | IF 1:200-1:1000ELISA 1:10000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
Gene Symbol: | GPR143 |
Gene ID: | 4935 |
Uniprot ID: | GP143_HUMAN |
Immunogen Region: | 151-200 aa |
Specificity: | GPR143 Polyclonal Antibody detects endogenous levels of GPR143 protein. |
Immunogen: | The antiserum was produced against synthesized peptide derived from the human GPR143 at the amino acid range 151-200 |
Description
Post Translational Modifications | Glycosylated. Phosphorylated. |
Function | Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane.this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Also plays a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport. |
Protein Name | G-Protein Coupled Receptor 143Ocular Albinism Type 1 Protein |
Database Links | Reactome: R-HSA-375280Reactome: R-HSA-416476 |
Cellular Localisation | Melanosome MembraneMulti-Pass Membrane ProteinLysosome MembraneApical Cell MembraneDistributed Throughout The Endo-Melanosomal System But Most Of Endogenous Protein Is Localized In Unpigmented Stage Ii MelanosomesIts Expression On The Apical Cell Membrane Is Sensitive To Tyrosine |
Alternative Antibody Names | Anti-G-Protein Coupled Receptor 143 antibodyAnti-Ocular Albinism Type 1 Protein antibodyAnti-GPR143 antibodyAnti-OA1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance