General Info
| Host: | Rabbit |
| Applications: | WB/IHC |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-KCNH2 (850-950) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
| Gene Symbol: | KCNH2 |
| Gene ID: | 3757 |
| Uniprot ID: | KCNH2_HUMAN |
| Immunogen Region: | 850-950 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 850-950 of human KCNH2 (NP_000229.1). |
| Immunogen Sequence: | DHFWSSLEITFNLRDTNMIP GSPGSTELEGGFSRQRKRKL SFRRRTDKDTEQPGEVSALG PGRAGAGPSSRGRPGGPWGE SPSSGPSSPESSEDEGPGRS S |
Description
| Tissue Specificity | Highly expressed in heart and brain. Isoforms USO are frequently overexpressed in cancer cells. |
| Post Translational Modifications | Phosphorylated on serine and threonine residues. Phosphorylation by PKA inhibits ion conduction. |
| Function | Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform A-USO: Has no channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation. Isoform B-USO: Has no channel activity by itself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation. |
| Protein Name | Potassium Voltage-Gated Channel Subfamily H Member 2Eag HomologEther-A-Go-Go-Related Gene Potassium Channel 1Erg-1Eag-Related Protein 1Ether-A-Go-Go-Related Protein 1H-ErgHerg-1Herg1Voltage-Gated Potassium Channel Subunit Kv11.1 |
| Database Links | Reactome: R-HSA-1296072Reactome: R-HSA-5576890 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Potassium Voltage-Gated Channel Subfamily H Member 2 antibodyAnti-Eag Homolog antibodyAnti-Ether-A-Go-Go-Related Gene Potassium Channel 1 antibodyAnti-Erg-1 antibodyAnti-Eag-Related Protein 1 antibodyAnti-Ether-A-Go-Go-Related Protein 1 antibodyAnti-H-Erg antibodyAnti-Herg-1 antibodyAnti-Herg1 antibodyAnti-Voltage-Gated Potassium Channel Subunit Kv11.1 antibodyAnti-KCNH2 antibodyAnti-ERG antibodyAnti-ERG1 antibodyAnti-HERG antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance