Mouse anti-Human/Cynomolgus Monkey/Rabbit PECAM-1 Antibody
Anti-Monkey/Rabbit PECAM-1 Antibody
Anti-Monkey/Rabbit PECAM-1 Antibody
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Product Description
Specifications
| Size | 20 µg, 100 µg |
| Species | Human |
| Specificity | Other species not known |
| Host Species | Mouse |
| Accession Number | P16284 |
| Gene Id | 5175 |
| Gene Symbols | PECAM1 |
| Protein Name / Synonyms | Platelet endothelial cell adhesion molecule (PECAM-1) (EndoCAM) (GPIIA') (PECA1) (CD antigen CD31) |
| Immunogen | Human recombinant PECAM-1 / CD31 protein was used as the immunogen for this antibody. |
| Isotype | Kappa, IgG1 |
| Purity | Protein G affinity chromatography |
| Concentration (lot specific) | 0.2 mg/ml in 1X PBS (pH 7.4) with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide |
| Recommended Applications | FACS: 0.5-1ug/10e6 cells IF: 1-2ug/ml Western Blotting: 0.5-1ug/ml IHC (FFPE): 0.5-1ug/ml for 30 minutes at RT (1) Prediluted format: incubate for 30 min at RT (2) |
| Domain / Region / Terminus | Cell surface and cytoplasmic |
| Research Area | Angiogenesis |
| Shipping Type | Blue ice |
| Storage | 2-8°C |
Description
PECAM-1, or platelet endothelial cell adhesion molecule-1, also called CD31, is made up of six extracellular immunoglobulin-like domains, a single transmembrane domain, and a cytoplasmic domain containing serine and tyrosine residues that when phosphorylated, activate the molecules signaling function. It is expressed on platelets, monocytes, neutrophils, bone marrow macrophage and dendritic cells precursors, and at the intracellular junction of endothelial cells. PECAM-1, on the endothelial lining of blood vessels, helps maintain the vascular barrier. In response to inflammatory mediators, the endothelial pull away from each other allowing fluid, inflammatory cells and proteins into the extravascular space. The inflammatory response fades as adhesion of neighboring cells increase. PECAM-1 also plays an important role in angiogenesis, promoting endothelial cell motility, junctional development and capillary morphogenesis.
Storage
Store the PECAM-1 antibody at 2-8°C.
Expiration:
12 months from the date of shipment when stored properly.