Anti-PDGFC antibody (61-110)

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	IHC-P 1:50-200 ELISA 1:10000-20000 IF 1:50-200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	PDGFC
Gene ID:	56034
Uniprot ID:	PDGFC_HUMAN
Immunogen Region:	61-110 aa
Specificity:	The antibody detects endogenous PDGF-C
Immunogen:	Synthetic peptide from the human protein at the amino acid range 61-110

Post Translational Modifications	Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after basic residues in the hinge region (region connecting the CUB and growth factor domains) gives rise to the receptor-binding form. Cleaved by PLAT and PLG. Sumoylated with SUMO1. N-glycosylated.
Function	Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.
Protein Name	Platelet-Derived Growth Factor C Pdgf-C Fallotein Spinal Cord-Derived Growth Factor Scdgf Vegf-E Cleaved Into - Platelet-Derived Growth Factor C - Latent Form Pdgfc Latent Form - Platelet-Derived Growth Factor C - Receptor-Binding Form Pdgfc Receptor-Binding Form
Database Links	Reactome: R-HSA-186797 Q9NRA1-1
Cellular Localisation	Cytoplasm Cytosol Secreted Nucleus Cytoplasmic Granule Cell Membrane Sumoylated Form Is Predominant In The Nucleus Stored In Alpha Granules In Platelets
Alternative Antibody Names	Anti-Platelet-Derived Growth Factor C antibody Anti-Pdgf-C antibody Anti-Fallotein antibody Anti-Spinal Cord-Derived Growth Factor antibody Anti-Scdgf antibody Anti-Vegf-E Cleaved Into - Platelet-Derived Growth Factor C - Latent Form antibody Anti-Pdgfc Latent Form - Platelet-Derived Growth Factor C - Receptor-Binding Form antibody Anti-Pdgfc Receptor-Binding Form antibody Anti-PDGFC antibody Anti-SCDGF antibody Anti-UNQ174 antibody Anti-PRO200 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance