General Info
| Host: | Rabbit |
| Applications: | WB/IHC/IHC-F/FC/ICC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat/D.melanogaster |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Phospho-Histone H3.1 and Histone H3.2 and Histone H3.3-Ser10 (1-50 aa) is suitable for use in Western Blot, Immunohistochemistry, Flow Cytometry, Immunocytochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300ICC IF 1:200-1:1000ELISA 1:10000IHC-fFC 1:500 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
| Gene Symbol: | H3C1.H3C2.H3C3.H3C4.H3C6.H3C7.H3C8.H3C10.H3C11.H3C128350/8351/8352/8353/8354/8355/8356/8357/8358/89681 |
| Uniprot ID: | H31_HUMANH32_HUMANH33_HUMAN< |
| Immunogen Region: | 1-50 aa |
| Specificity: | Phospho-Histone H3 (S10) Polyclonal Antibody detects endogenous levels of Histone H3 protein only when phosphorylated at S10. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human Histone H3.1 around the phosphorylation site of Ser10 at the amino acid range 1-50 |
Description
| Function | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
| Protein Name | Histone H3.1Histone H3/AHistone H3/BHistone H3/CHistone H3/DHistone H3/FHistone H3/HHistone H3/IHistone H3/JHistone H3/KHistone H3/L |
| Database Links | Reactome: R-HSA-1266695Reactome: R-HSA-1912408Reactome: R-HSA-201722Reactome: R-HSA-212300Reactome: R-HSA-2299718Reactome: R-HSA-2559580Reactome: R-HSA-2559582Reactome: R-HSA-3214815Reactome: R-HSA-3214841Reactome: R-HSA-3214842Reactome: R-HSA-3214847Reactome: R-HSA-3214858Reactome: R-HSA-3247509Reactome: R-HSA-427359Reactome: R-HSA-427389Reactome: R-HSA-427413Reactome: R-HSA-5250924Reactome: R-HSA-5334118Reactome: R-HSA-5578749Reactome: R-HSA-5617472Reactome: R-HSA-5625886Reactome: R-HSA-73728Reactome: R-HSA-73772Reactome: R-HSA-8936459Reactome: R-HSA-8939236Reactome: R-HSA-9018519Reactome: R-HSA-912446Reactome: R-HSA-9609690Reactome: R-HSA-9610379Reactome: R-HSA-9616222Reactome: R-HSA-977225Reactome: R-HSA-983231 |
| Cellular Localisation | NucleusChromosome |
| Alternative Antibody Names | Anti-Histone H3.1 antibodyAnti-Histone H3/A antibodyAnti-Histone H3/B antibodyAnti-Histone H3/C antibodyAnti-Histone H3/D antibodyAnti-Histone H3/F antibodyAnti-Histone H3/H antibodyAnti-Histone H3/I antibodyAnti-Histone H3/J antibodyAnti-Histone H3/K antibodyAnti-Histone H3/L antibodyAnti-H3C1 antibodyAnti-H3FA antibodyAnti-HIST1H3A.H3C2 antibodyAnti-H3FL antibodyAnti-HIST1H3B.H3C3 antibodyAnti-H3FC antibodyAnti-HIST1H3C.H3C4 antibodyAnti-H3FB antibodyAnti-HIST1H3D.H3C6 antibodyAnti-H3FD antibodyAnti-HIST1H3E.H3C7 antibodyAnti-H3FI antibodyAnti-HIST1H3F.H3C8 antibodyAnti-H3FH antibodyAnti-HIST1H3G.H3C10 antibodyAnti-H3FK antibodyAnti-HIST1H3H.H3C11 antibodyAnti-H3FF antibodyAnti-HIST1H3I.H3C12 antibodyAnti-H3FJ antibodyAnti-HIST1H3J antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance