General Info
| Host: | Rabbit |
| Applications: | WB/IHC/IF |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-PTRF (200-390) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000IHC-P 1:50-1:200IF/ICC 1:50-1:200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
| Gene Symbol: | CAVIN1 |
| Gene ID: | 284119 |
| Uniprot ID: | CAVN1_HUMAN |
| Immunogen Region: | 200-390 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-390 of human PTRF (NP_036364.2). |
| Immunogen Sequence: | ELSSDEAVEVEEVIEESRAE RIKRSGLRRVDDFKKAFSKE KMEKTKVRTRENLEKTRLKT KENLEKTRHTLEKRMNKLGT R |
Description
| Post Translational Modifications | Phosphorylated. Present in active and inactive forms. Changes in phosphorylation pattern may alter activity. Phosphorylation at Tyr-156 is essential for its functionin the regulation of ribosomal transcriptional activity. Five truncated forms are found in the caveolae. These are thought to be the result of proteolysis and may be phosphorylation-dependent. Monoubiquitinated. |
| Function | Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues. Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA-bound TTF1, thereby releasing both RNA polymerase I and pre-RNA from the template. The caveolae biogenesis pathway is required for the secretion of proteins such as GASK1A. |
| Protein Name | Caveolae-Associated Protein 1Cavin-1Polymerase I And Transcript Release Factor |
| Database Links | Reactome: R-HSA-73863Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106 |
| Cellular Localisation | MembraneCaveolaCell MembraneMicrosomeEndoplasmic ReticulumCytoplasmCytosolMitochondrionNucleusTranslocates To The Cytoplasm From The Caveolae Upon Insulin StimulationColocalizes With Cav1 In Lipid Rafts In AdipocytesLocalizes In The Caveolae In A Caveolin-Dependent Manner |
| Alternative Antibody Names | Anti-Caveolae-Associated Protein 1 antibodyAnti-Cavin-1 antibodyAnti-Polymerase I And Transcript Release Factor antibodyAnti-CAVIN1 antibodyAnti-PTRF antibodyAnti-FKSG13 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance