Anti-SLC1A5 antibody

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	SLC1A5
Gene ID:	6510
Uniprot ID:	AAAT_HUMAN
Immunogen Region:	345-395 aa
Specificity:	This antibody detects endogenous levels of AAAT at Human/Mouse
Immunogen:	Synthesized peptide derived from the human the amino acidAT at the amino acid range 345-395

Function	Sodium-coupled antiporter of neutral amino acids. In a tri-substrate transport cycle, exchanges neutral amino acids between the extracellular and intracellular compartments, coupled to the inward cotransport of at least one sodium ion. The preferred substrate is the essential amino acid L-glutamine, a precursor for biosynthesis of proteins, nucleotides and amine sugars as well as an alternative fuel for mitochondrial oxidative phosphorylation. Exchanges L-glutamine with other neutral amino acids such as L-serine, L-threonine and L-asparagine in a bidirectional way. Provides L-glutamine to proliferating stem and activated cells driving the metabolic switch toward cell differentiation. The transport cycle is usually pH-independent, with the exception of L-glutamate. Transports extracellular L-glutamate coupled to the cotransport of one proton and one sodium ion in exchange for intracellular L-glutamine counter-ion. May provide for L-glutamate uptake in glial cells regulating glutamine/glutamate cycle in the nervous system. Can transport D-amino acids. Mediates D-serine release from the retinal glia potentially affecting NMDA receptor function in retinal neurons. Displays sodium- and amino acid-dependent but uncoupled channel-like anion conductance with a preference SCN(-) >> NO3(-) > I(-) > Cl(-). Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development. (Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114. (Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus. (Microbial infection) Acts as a cell surface receptor for type D simian retroviruses.
Protein Name	Neutral Amino Acid Transporter B(0 Atb(0 Baboon M7 Virus Receptor Rd114/Simian Type D Retrovirus Receptor Sodium-Dependent Neutral Amino Acid Transporter Type 2 Solute Carrier Family 1 Member 5
Database Links	Reactome: R-HSA-352230 Reactome: R-HSA-9013149 Reactome: R-HSA-9013406 Reactome: R-HSA-9013407 Reactome: R-HSA-9013409 Reactome: R-HSA-9013423
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Melanosome Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv
Alternative Antibody Names	Anti-Neutral Amino Acid Transporter B(0 antibody Anti-Atb(0 antibody Anti-Baboon M7 Virus Receptor antibody Anti-Rd114/Simian Type D Retrovirus Receptor antibody Anti-Sodium-Dependent Neutral Amino Acid Transporter Type 2 antibody Anti-Solute Carrier Family 1 Member 5 antibody Anti-SLC1A5 antibody Anti-ASCT2 antibody Anti-M7V1 antibody Anti-RDR antibody Anti-RDRC antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance