General Info
| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-SLC5A3 (535-695) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
| Gene Symbol: | SLC5A3Uniprot ID=SC5A3_HUMAN" |
| Immunogen Region: | 535-695 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 535-695 of human SLC5A3 (NP_008864.4). |
| Immunogen Sequence: | PPTKEQIRTTTFWSKKNLVV KENCSPKEEPYKMQEKSILR CSENNETINHIIPNGKSEDS IKGLQPEDVNLLVTCREEGN PVASLGHSEAETPVDAYSNG QAALMGEKERKKETDDGGRY WKFIDWFCGFKSKSLSKRSL RDLMEEEAVCLQMLEETRQV K |
Description
| Function | Electrogenic Na(+)-coupled sugar symporter that actively transports myo-inositol and its stereoisomer scyllo-inositol across the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1. Maintains myo-inositol concentration gradient that defines cell volume and fluid balance during osmotic stress, in particular in the fetoplacental unit and central nervous system. Forms coregulatory complexes with voltage-gated K(+) ion channels, allosterically altering ion selectivity, voltage dependence and gating kinetics of the channel. In turn, K(+) efflux through the channel forms a local electrical gradient that modulates electrogenic Na(+)-coupled myo-inositol influx through the transporter. Associates with KCNQ1-KCNE2 channel in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability. Associates with KCNQ2-KCNQ3 channel altering ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) permeation. Provides myo-inositol precursor for biosynthesis of phosphoinositides such as PI(4,5)P2, thus indirectly affecting the activity of phosphoinositide-dependent ion channels and Ca(2+) signaling upon osmotic stress. |
| Protein Name | Sodium/Myo-Inositol CotransporterNa(+/Myo-Inositol CotransporterSodium/Myo-Inositol Transporter 1Smit1Solute Carrier Family 5 Member 3 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneColocalizes With Kcnq1 At The Apical Membrane Of Choroid Plexus Epithelium |
| Alternative Antibody Names | Anti-Sodium/Myo-Inositol Cotransporter antibodyAnti-Na(+/Myo-Inositol Cotransporter antibodyAnti-Sodium/Myo-Inositol Transporter 1 antibodyAnti-Smit1 antibodyAnti-Solute Carrier Family 5 Member 3 antibodyAnti-SLC5A3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance