Anti-SMC3 antibody

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IP 1:500-1:1000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	SMC3
Gene ID:	9126
Uniprot ID:	SMC3_HUMAN
Immunogen Region:	909-1199
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 909-1199 of human SMC3 (NP_005436.1).
Immunogen Sequence:	KEHMDAINHDTKELEKMTNR QGMLLKKKEECMKKIRELGS LPQEAFEKYQTLSLKQLFRK LEQCNTELKKYSHVNKKALD QFVNFSEQKEKLIKRQEELD RGYKSIMELMNVLELRKYEA IQLTFKQVSKNFSEVFQKLV PGGKATLVMKKGDVEGSQSQ DEGEGSGESERGSGSQSSVP SVDQFTGVGIRVSFTGKQGE MREMQQLSGGQKSLVALALI FAIQKCDPAPFYLFDEIDQ

Post Translational Modifications	Ubiquitinated by the DCX(DCAF15) complex, leading to its degradation. Phosphorylated at Ser-1083 in a SPO11-dependent manner. Acetylation at Lys-105 and Lys-106 by ESCO1 is important for genome stability and S phase sister chromatid cohesion. Regulated by DSCC1, it is required for processive DNA synthesis, coupling sister chromatid cohesion establishment during S phase to DNA replication. Deacetylation by HDAC8, regulates release of the cohesin complex from chromatin.
Function	Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.
Protein Name	Structural Maintenance Of Chromosomes Protein 3 Smc Protein 3 Smc-3 Basement Membrane-Associated Chondroitin Proteoglycan Bamacan Chondroitin Sulfate Proteoglycan 6 Chromosome-Associated Polypeptide Hcap
Database Links	Reactome: R-HSA-1221632 Reactome: R-HSA-2467813 Reactome: R-HSA-2468052 Reactome: R-HSA-2470946 Reactome: R-HSA-2500257 Reactome: R-HSA-3108214 Reactome: R-HSA-9018519
Cellular Localisation	Nucleus Chromosome Centromere Associates With Chromatin Before Prophase It Is Scattered Along Chromosome Arms During Prophase Most Of Cohesin Complexes Dissociate From Chromatin Probably Because Of Phosphorylation By Plk Except At Centromeres Where Cohesin Complexes Remain At Anaphase The Rad21 Subunit Of The Cohesin Complex Is Cleaved Leading To The Dissociation Of The Complex From Chromosomes Allowing Chromosome Separation The Phosphorylated Form At Ser-1083 Is Preferentially Associated With Unsynapsed Chromosomal Regions
Alternative Antibody Names	Anti-Structural Maintenance Of Chromosomes Protein 3 antibody Anti-Smc Protein 3 antibody Anti-Smc-3 antibody Anti-Basement Membrane-Associated Chondroitin Proteoglycan antibody Anti-Bamacan antibody Anti-Chondroitin Sulfate Proteoglycan 6 antibody Anti-Chromosome-Associated Polypeptide antibody Anti-Hcap antibody Anti-SMC3 antibody Anti-BAM antibody Anti-BMH antibody Anti-CSPG6 antibody Anti-SMC3L1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance